MicroRNA as Biomarkers and Diagnostics

被引：656
作者：
Wang, Jin [1 ]
Chen, Jinyun [2 ]
Sen, Subrata [1 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
[3] Univ Texas Houston, Grad Sch Biomed Sci, Program Human & Mol Genet, Houston, TX USA
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2016年 / 231卷 / 01期
基金：
美国国家卫生研究院;
关键词：
TUMOR-SUPPRESSOR GENE; CIRCULATING MICRORNAS; POTENTIAL BIOMARKER; NONCODING RNAS; EXPRESSED MICRORNAS; ALZHEIMERS-DISEASE; MESSENGER-RNA; LUNG-CANCER; SIGNATURE; SERUM;
D O I：
10.1002/jcp.25056
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNAs (miRNAs) are a group of small non-coding RNAs that are involved in regulating a range of developmental and physiological processes; their dysregulation has been associated with development of diseases including cancer. Circulating miRNAs and exosomal miRNAs have also been proposed as being useful in diagnostics as biomarkers for diseases and different types of cancer. In this review, miRNAs are discussed as biomarkers for cancer and other diseases, including viral infections, nervous system disorders, cardiovascular disorders, and diabetes. We summarize some of the clinical evidence for the use of miRNAs as biomarkers in diagnostics and provide some general perspectives on their use in clinical situations. The analytical challenges in using miRNAs in cancer and disease diagnostics are evaluated and discussed. Validation of specific miRNA signatures as biomarkers is a critical milestone in diagnostics. J. Cell. Physiol. 230: 25-30, 2016. (c) 2015 Wiley Periodicals, Inc.
引用
收藏
页码：25 / 30
页数：6
相关论文
共 118 条
[1]   Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].
Abelson, JF ;
Kwan, KY ;
O'Roak, BJ ;
Baek, DY ;
Stillman, AA ;
Morgan, TM ;
Mathews, CA ;
Pauls, DA ;
Rasin, MR ;
Gunel, M ;
Davis, NR ;
Ercan-Sencicek, AG ;
Guez, DH ;
Spertus, JA ;
Leckman, JF ;
Dure, LS ;
Kurlan, R ;
Singer, HS ;
Gilbert, DL ;
Farhi, A ;
Louvi, A ;
Lifton, RP ;
Sestan, N ;
State, MW .
SCIENCE, 2005, 310 (5746) :317-320
[2]   Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction [J].
Ai, Jing ;
Zhang, Rong ;
Li, Yue ;
Pu, Jielin ;
Lu, Yanjie ;
Jiao, Jundong ;
Li, Kang ;
Yu, Bo ;
Li, Zhuqin ;
Wang, Rongrong ;
Wang, Lihong ;
Li, Qiang ;
Wang, Nina ;
Shan, Hongli ;
Li, Zhongyu ;
Yang, Baofeng .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (01) :73-77
[3]   MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function [J].
Albinsson, Sebastian ;
Suarez, Yajaira ;
Skoura, Athanasia ;
Offermanns, Stefan ;
Miano, Joseph M. ;
Sessa, William C. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (06) :1118-U80
[4]   The functions of animal microRNAs [J].
Ambros, V .
NATURE, 2004, 431 (7006) :350-355
[5]   Circulating MicroRNAs as a Marker for Liver Injury in Human Immunodeficiency Virus Patients [J].
Anadol, Evrim ;
Schierwagen, Robert ;
Elfimova, Natalia ;
Tack, Katharina ;
Schwarze-Zander, Carolynne ;
Eischeid, Hanna ;
Noetel, Andrea ;
Boesecke, Christoph ;
Jansen, Christian ;
Dold, Leona ;
Wasmuth, Jan-Christian ;
Strassburg, Christian P. ;
Spengler, Ulrich ;
Rockstroh, Juergen Kurt ;
Odenthal, Margarete ;
Trebicka, Jonel .
HEPATOLOGY, 2015, 61 (01) :46-55
[6]   MicroRNA expression differentiates between primary lung tumors and metastases to the lung [J].
Barshack, Iris ;
Lithwick-Yanai, Gila ;
Afek, Arnon ;
Rosenblatt, Kinneret ;
Tabibian-Keissar, Hila ;
Zepeniuk, Merav ;
Cohen, Lahav ;
Dan, Harel ;
Zion, Orit ;
Strenov, Yulia ;
Polak-Charcon, Sylvie ;
Perelman, Marina .
PATHOLOGY RESEARCH AND PRACTICE, 2010, 206 (08) :578-584
[7]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[8]   Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder [J].
Bavamian, S. ;
Mellios, N. ;
Lalonde, J. ;
Fass, D. M. ;
Wang, J. ;
Sheridan, S. D. ;
Madison, J. M. ;
Zhou, Fen ;
Rueckert, E. H. ;
Barker, D. ;
Perlis, R. H. ;
Sur, M. ;
Haggarty, S. J. .
MOLECULAR PSYCHIATRY, 2015, 20 (05) :573-584
[9]   Urine MicroRNA as Potential Biomarkers of Autosomal Dominant Polycystic Kidney Disease Progression: Description of miRNA Profiles at Baseline [J].
Ben-Dov, Iddo Z. ;
Tan, Ying-Cai ;
Morozov, Pavel ;
Wilson, Patricia D. ;
Rennert, Hanna ;
Blumenfeld, Jon D. ;
Tuschl, Thomas .
PLOS ONE, 2014, 9 (01)
[10]   Dicer is essential for mouse development [J].
Bernstein, E ;
Kim, SY ;
Carmell, MA ;
Murchison, EP ;
Alcorn, H ;
Li, MZ ;
Mills, AA ;
Elledge, SJ ;
Anderson, KV ;
Hannon, GJ .
NATURE GENETICS, 2003, 35 (03) :215-217
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