Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis

被引：26

作者：

Yang, Yanlong ^{[1
]}

Zhang, Yuting ^{[1
,2
]}

Zhang, Shasha ^{[3
]}

Chen, Qingwen ^{[4
]}

Ma, Ke ^{[1
,2
]}

Bao, Li ^{[1
,2
]}

Tao, Yong ^{[3
]}

Yin, Wenbing ^{[1
,2
]}

Wang, Guodong ^{[4
]}

Liu, Hongwei ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China

[4] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 04期

基金：

中国国家自然科学基金;

关键词：

BIOSYNTHETIC GENE-CLUSTER; GENOME MINING APPROACH; BACILLUS-CLAUSII; TERPENE CYCLASE; SYNTHASE; DITERPENE; DISCOVERY; PRENYLTRANSFERASES; SESQUARTERPENES; BRASSICACEAE;

D O I：

10.1021/acs.jnatprod.7b01033

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sesterterpenes are usually found in plants and fungi, but are rare in bacteria. Here, we present the identification of StsC from Streptomyces somaliensis, a member of the UbiA superfamily, as a membrane-bound sesterterpene cyclase in bacteria. The cyclized products for StsC, somaliensenes A (1) and B (2), were identified by expressing the corresponding gene in an engineered Escherichia coli strain. The structures of 1 and 2 were determined by analysis of the NMR and MS spectroscopic data.

引用

页码：1089 / 1092

页数：4

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