Source Localization of Temporal Lobe Epilepsy Using PCA-LORETA Analysis on Ictal EEG Recordings

被引:20
作者
Stern, Yaki [1 ]
Neufeld, Miriam Y. [2 ,3 ]
Kipervasser, Svetlana [2 ,3 ]
Zilberstein, Amir [1 ,4 ]
Fried, Itzhak [5 ,6 ]
Teicher, Mina [1 ,4 ]
Adi-Japha, Esther [1 ,6 ]
机构
[1] Bar Ilan Univ, Leslie & Susan Gonda Goldschmied Multidisciplinar, Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Dept Neurol, Tel Aviv Sourasky Med Ctr,EEG, IL-69978 Tel Aviv, Israel
[3] Tel Aviv Univ, Sackler Sch Med, Dept Neurol, Tel Aviv Sourasky Med Ctr,Epilepsy Unit, IL-69978 Tel Aviv, Israel
[4] Bar Ilan Univ, Dept Math, Ramat Gan, Israel
[5] Tel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr, Funct Neurosurg Unit,Dept Neurosurg, IL-69978 Tel Aviv, Israel
[6] Bar Ilan Univ, Sch Educ, Ramat Gan, Israel
关键词
Epilepsy; PCA; LORETA; Source localization; INDEPENDENT COMPONENT ANALYSIS; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; EVENT-RELATED-POTENTIALS; EPILEPTIFORM DISCHARGES; DYNAMICS; ORIGIN; DOMAIN; ICA;
D O I
10.1097/WNP.0b013e31819b3bf2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Localizing the source of ail epileptic seizure using noninvasive EEG suffers from inaccuracies produced by other generators not related to the epileptic source. The authors isolated file ictal epileptic activity, and applied a Source localization algorithm to identify its estimated location. Ten ictal EEG scalp recordings from five different patients were analyzed. The patients were known to have temporal lobe epilepsy with a single epileptic focus that had a concordant MRI lesion. The patients had become seizure-free following partial temporal lobectomy. A midinterval (similar to 5 seconds) period of ictal activity was used for Principal Component Analysis starting at ictal onset. The level of epileptic activity at each electrode (i.e., the eigenvector of the component that manifest epileptic characteristic), was used its an input for low-resolution tomography analysis for EEG inverse solution (Zilberstain et al., 2004). The algorithm accurately and robustly identified the epileptic focus in these patients. Principal component analysis and source localization methods can be used in the future to monitor the progression of an epileptic seizure and its expansion to other areas.
引用
收藏
页码:109 / 116
页数:8
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