The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria

被引:8
作者
Spat, Andras [1 ,2 ]
Szanda, Gergo [1 ]
机构
[1] Semmelweis Univ, Sch Med, Dept Physiol, POB 2, H-1428 Budapest, Hungary
[2] Hungarian Acad Sci, Lab Mol Physiol, Budapest, Hungary
来源
STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION | 2017年 / 993卷
关键词
Store-operated Ca2+ entry; Mitochondria; Ca2+ uptake; Ca2+ release; Microdomains; NAD(P)H; Membrane potential; CAPACITATIVE CALCIUM-ENTRY; ENDOPLASMIC-RETICULUM; PLASMA-MEMBRANE; CRAC CHANNELS; DEPENDENT INACTIVATION; ESSENTIAL COMPONENT; INTRACELLULAR CA2+; CYTOPLASMIC CA2+; ATP SYNTHESIS; RAT-LIVER;
D O I
10.1007/978-3-319-57732-6_14
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria extensively modify virtually all cellular Ca2+ transport processes, and store-operated Ca2+ entry (SOCE) is no exception to this rule. The interaction between SOCE and mitochondria is complex and reciprocal, substantially altering and, ultimately, fine-tuning both capacitative Ca2+ influx and mitochondrial function. Mitochondria, owing to their considerable Ca2+ accumulation ability, extensively buffer the cytosolic Ca2+ in their vicinity. In turn, the accumulated ion is released back into the neighboring cytosol during net Ca2+ efflux. Since store depletion itself and the successive SOCE are both Ca(2+)regulated phenomena, mitochondrial Ca2+ handling may have wide-ranging effects on capacitative Ca2+ influx at any given time. In addition, mitochondria may also produce or consume soluble factors known to affect store-operated channels. On the other hand, Ca2+ entering the cell during SOCE is sensed by mitochondria, and the ensuing mitochondrial Ca2+ uptake boosts mitochondrial energy metabolism and, if Ca2+ overload occurs, may even lead to apoptosis or cell death. In several cell types, mitochondria seem to be sterically excluded from the confined space that forms between the plasma membrane (PM) and endoplasmic reticulum (ER) during SOCE. This implies that high-Ca2+ microdomains comparable to those observed between the ER and mitochondria do not form here. In the following chapter, the above aspects of the many-sided SOCE-mitochondrion interplay will be discussed in greater detail.
引用
收藏
页码:257 / 275
页数:19
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