Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats

被引：32

作者：

Murthy, Hosakatte Niranjana ^{[1
,2
]}

Dandin, Vijayalaxmi S. ^{[2
]}

Lee, Eun Jung ^{[3
]}

Paek, Kee Yoeup ^{[1
,3
]}

机构：

[1] Chungbuk Natl Univ, Res Ctr Dev Adv Hort Technol, Cheongju 361763, South Korea

[2] Karnatak Univ, Dept Bot, Dharwad 580003, Karnataka, India

[3] Chungbuk Natl Univ, Cheongsol Biotech Co Ltd, Ind Acad Cooperat Fdn, Agribusiness Incubator Ctr, Cheongju 361763, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2014年 / 153卷 / 03期

关键词：

Antidiabetic; Blood glucose; Dietary supplement; Ginsenosides; PANAX-GINSENG; METHYL JASMONATE; ACCUMULATION; GINSENOSIDES; ANTIOXIDANT; CULTURE; GLUCOSE;

D O I：

10.1016/j.jep.2014.03.062

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethno pharmacological relevance: Ginseng has various bioactive effects on human health including its potential activity of improving the glucose homeostasis and insulin sensitivity. Materials and methods: Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract enriched with ginsenosides was used as experimental material. Streptozotocin-induced diabetic 'Sprague Dawley' male rats were used as experimental systems and were fed with Tissue culture raised mountain ginseng adventitious root extract. Field cultivated Korean ginseng root extract fed rats were used as positive control and several indices such as body weight, blood glucose level and other serological indicators were tested. Results: Chemical profile showed TCMGARs were rich in varied ginsenosides especially Rb1, Rb2, Rc, Rd, Rg3, and Rh2 when compared to field cultivated Korean ginseng. TCMGARs extract at dosage levels of 250 and 500 mg/kg body weight significantly lowered the blood glucose, total cholesterol and triglyceride content in streptozotocin-induced diabetic rats. Conclusion: The data of in vivo experiments on anti-glycemic effects of TCMGARs proves their efficacy and also their use as dietary supplement. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：917 / 921

页数：5

共 24 条

[1] Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors [J].

Ali, Mohammad Babar ;

Yu, Kee-Won ;

Hahn, Eun-Joo ;

Paek, Kee-Yoeup .

PLANT CELL REPORTS, 2006, 25 (06) :613-620

[2] Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component [J].

Attele, AS ;

Zhou, YP ;

Xie, JT ;

Wu, JA ;

Zhang, L ;

Dey, L ;

Pugh, W ;

Rue, PA ;

Polonsky, KS ;

Yuan, CS .

DIABETES, 2002, 51 (06) :1851-1858

[3] Ginseng pharmacology - Multiple constituents and multiple actions [J].

Attele, AS ;

Wu, JA ;

Yuan, CS .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (11) :1685-1693

[4] Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants [J].

Bae, EA ;

Han, MJ ;

Kim, EJ ;

Kim, DH .

ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (01) :61-67

[5]

Georg P., 2000, J Clin Basic Cardiol, V3, P159

[6]

Gilman A.G., 1990, GOODMAN GILMANS PHAR

[7] A REVIEW OF NATURAL-PRODUCTS AND PLANTS AS POTENTIAL ANTIDIABETIC DRUGS [J].

IVORRA, MD ;

PAYA, M ;

VILLAR, A .

JOURNAL OF ETHNOPHARMACOLOGY, 1989, 27 (03) :243-275

[8] Antidiabetic herbal drugs officially approved in China [J].

Jia, W ;

Gao, WY ;

Tang, L .

PHYTOTHERAPY RESEARCH, 2003, 17 (10) :1127-1134

[9] Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats [J].

Kim, Hyun-Jeong ;

Chae, In-Gyeong ;

Lee, Sung-Gyu ;

Jeong, Hyun-Jin ;

Lee, Eun-Ju ;

Lee, In-Seon .

JOURNAL OF GINSENG RESEARCH, 2010, 34 (02) :104-112

[10] Adventitious root growth and ginsenoside accumulation in Panax ginseng cultures as affected by methyl jasmonate [J].

Kim, YS ;

Hahn, EJ ;

Murthy, HN ;

Paek, KY .

BIOTECHNOLOGY LETTERS, 2004, 26 (21) :1619-1622

← 1 2 3 →