Synthesis, analgesic, anti inflammatory and antimicrobial activities of naphtho [2,1-b] furan incorporated substituted pyrimidines

2-Hydroxyl-1-naphthaldehyde 2 when treated with bromoacetone in presence of anhydrous K2CO3 and dry acetone, underwent condensation and cyclization in a single step to give 2-acetylnaphtho (2,1-b] furan 3 as pale yellow crystals. 3-(Substituted phenyl)1-napltho[2, 1-b] furan-2-yl-prop-2-en-1-ones 4a-h were prepared by the reaction of 3 with different aromatic aldehydes in the presence of a strong base. Cyclocondensation of 4a-h with guanidine hydrochloride, thiourea and urea resulted in the formation of various 4-(aryl substituted)-6-naphtho [2,1-b] furan-2-yl) pyrimidin-2-amines 5a-h, 4-(aryl substituted)-6-naphtho [2, 1-b] furan-2-yl)pyrimidine-2-thiols 6a-h and 4-(aryl subtituted)6-naphtho [2,1-b] furan-2-yl) pyrimidin-2-ols 7a-h respectively. The structures of all newly synthesized compounds 5a-h, 6a-h and 7a-h have been established on the basis of analytical and spectral data. The compounds synthesized have been screened for antimicrobial activity. Few selected compounds have also been screened for analgesic and antiinflammatory activity.