Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl) Sulfides Using Heteroaryl Ethers and S-Heteroaryl Thioesters via Heteroarylthio Exchange

被引：21

作者：

Arisawa, Mieko ^{[1
]}

Tazawa, Takeru ^{[1
]}

Tanii, Saori ^{[1
]}

Horiuchi, Kiyofumi ^{[1
]}

Yamaguchi, Masahiko ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 01期

关键词：

COUPLING REACTIONS; ARYL HALIDES; IN-VIVO; THIOETHERS; SUBSTITUTION; INHIBITORS; SULFOXIDES; MECHANISM; PHENOLS; THIOLS;

D O I：

10.1021/acs.joc.6b02585

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unsymmetric di(heteroaryl) sulfides were synthesized by a rhodium-catalyzed heteroarylthio exchange reaction of heteroaryl aryl ethers and S-(heteroaryl) thioesters. The reaction has broad applicability, giving diverse unsymmetric di(heteroaryl) sulfides containing five- and six-membered heteroarenes. No base is required in this reaction, which has been developed by the judicious design of organic substrates.

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页码：804 / 810

页数：7

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