Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers

被引：26
|
作者：
Zhang, Xiaoli [1 ]
Pan, Zui [2 ]
机构：
[1] Ohio State Univ, Dept Biomed Informat, Columbus, OH 43201 USA
[2] Univ Texas Arlington, Coll Nursing & Hlth Innovat, Arlington, TX 76010 USA
来源：
GASTROENTEROLOGY REPORT | 2020年 / 8卷 / 03期
基金：
美国国家卫生研究院;
关键词：
dysbiosis; tumor microenvironment; proton-pump inhibitors; antibiotics; checkpoint inhibitors; H; pylori; HELICOBACTER-PYLORI; MOLECULAR CHARACTERIZATION; INTESTINAL METAPLASIA; BACTERIAL BIOTA; GUT MICROBIOME; RISK; INFLAMMATION; THERAPY; EFFICACY; STOMACH;
D O I：
10.1093/gastro/goaa014
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer.
引用
收藏
页码：206 / 214
页数：9
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