Total synthesis of (-)-renieramycin G from L-tyrosine

被引：49

作者：

Liao, Xiang Wei ^{[1
,2
,3
]}

Liu, Wei ^{[1
,2
,3
]}

Dong, Wen Fang ^{[1
,2
,3
]}

Guan, Bao He ^{[1
,2
,3
]}

Chen, Shi Zhi ^{[1
,2
,3
]}

Liu, Zhan Zhu ^{[1
,2
,3
]}

机构：

[1] Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

TETRAHEDRON | 2009年 / 65卷 / 29-30期

关键词：

ADRENERGIC-RECEPTOR ANTAGONIST; TETRAHYDROISOQUINOLINE ANTITUMOR ANTIBIOTICS; SPENGLER CYCLIZATION REACTIONS; ALPHA-AMINO-ALDEHYDES; DIRECTED CONDENSATION; ECTEINASCIDIN; 743; ABC RING; SAFRAMYCIN; DERIVATIVES; MY336-A;

D O I：

10.1016/j.tet.2009.05.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Renieramycin G was synthesized in 21 steps for the longest linear sequences employing L-tyrosine methyl ester as the chiral starting material in 8.5% overall yield. Two of the four chiral centers came from L-tyrosine methyl ester, and the other two were induced through an intermolecular and an intramolecular Pictet-Spengler reaction, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5709 / 5715

页数：7

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