Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

被引：496

作者：

Leung, Kathy ^{[1
,2
]}

Shum, Marcus H. H. ^{[1
,2
,3
,4
]}

Leung, Gabriel M. ^{[1
,2
]}

Lam, Tommy T. Y. ^{[1
,2
,3
,4
]}

Wu, Joseph T. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Sch Publ Hlth, Hong Kong, Peoples R China

[2] Lab Data Discovery Hlth D24H, Hong Kong Sci Pk, Hong Kong, Peoples R China

[3] Univ Hong Kong, Sch Publ Hlth, State Key Lab Emerging Infect Dis, Hong Kong, Peoples R China

[4] Shantou Univ, Joint Inst Virol Shantou Univ & Univ Hong Kong, Guangdong Hongkong Joint Lab Emerging Infect Dis, Shantou, Peoples R China

来源：

EUROSURVEILLANCE | 2021年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.2807/1560-7917.ES.2020.26.1.2002106

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Delta 69/Delta 70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Delta 69/Delta 70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.

引用

页码：15 / 21

页数：7

共 20 条

[1]

[Anonymous], 2020, UPD NEW SARS COV 2 V

[2]

BBC News, 2020, BBC News

[3]

Bloom JD, 2020, SARS COV 2 RBD DMS

[4]

COVID-19 Genomics UK (COG-UK) Consortium, COG UK 2020 12 20 SA

[5] An interactive web-based dashboard to track COVID-19 in real time [J].

Dong, Ensheng ;

Du, Hongru ;

Gardner, Lauren .

LANCET INFECTIOUS DISEASES, 2020, 20 (05) :533-534

[6]

Kemp S, 2020, BIORXIV

[7]

Kemp SA, 2020, NEUTRALISING ANTIBOD

[8]

Leung J.T., 2020, EMPIRICAL TRANSMISSI, DOI [10.1101/2020.09.22.20199810, DOI 10.1101/2020.09.22.20199810V1]

[9] First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment [J].

Leung, Kathy ;

Wu, Joseph T. ;

Liu, Di ;

Leung, Gabriel M. .

LANCET, 2020, 395 (10233) :1382-1393

[10]

Leung K, 2017, LANCET INFECT DIS, V17, P339, DOI [10.1016/S1473-3099(16)30465-0, 10.1016/s1473-3099(16)30465-0]

← 1 2 →