Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

被引：489
作者：
Leung, Kathy [1 ,2 ]
Shum, Marcus H. H. [1 ,2 ,3 ,4 ]
Leung, Gabriel M. [1 ,2 ]
Lam, Tommy T. Y. [1 ,2 ,3 ,4 ]
Wu, Joseph T. [1 ,2 ]
机构：
[1] Univ Hong Kong, LKS Fac Med, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Sch Publ Hlth, Hong Kong, Peoples R China
[2] Lab Data Discovery Hlth D24H, Hong Kong Sci Pk, Hong Kong, Peoples R China
[3] Univ Hong Kong, Sch Publ Hlth, State Key Lab Emerging Infect Dis, Hong Kong, Peoples R China
[4] Shantou Univ, Joint Inst Virol Shantou Univ & Univ Hong Kong, Guangdong Hongkong Joint Lab Emerging Infect Dis, Shantou, Peoples R China
来源：
EUROSURVEILLANCE | 2021年 / 26卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.2807/1560-7917.ES.2020.26.1.2002106
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Delta 69/Delta 70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Delta 69/Delta 70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.
引用
收藏
页码：15 / 21
页数：7
相关论文
共 20 条
  • [1] [Anonymous], 2020, UPD NEW SARS COV 2 V
  • [2] BBC News, 2020, BBC News
  • [3] Bloom JD, 2020, SARS COV 2 RBD DMS
  • [4] COVID-19 Genomics UK (COG-UK) Consortium, COG UK 2020 12 20 SA
  • [5] An interactive web-based dashboard to track COVID-19 in real time
    Dong, Ensheng
    Du, Hongru
    Gardner, Lauren
    [J]. LANCET INFECTIOUS DISEASES, 2020, 20 (05) : 533 - 534
  • [6] Kemp S, 2020, BIORXIV
  • [7] Kemp SA, 2020, NEUTRALISING ANTIBOD
  • [8] Leung J.T., 2020, EMPIRICAL TRANSMISSI, DOI [10.1101/2020.09.22.20199810, DOI 10.1101/2020.09.22.20199810V1]
  • [9] First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment
    Leung, Kathy
    Wu, Joseph T.
    Liu, Di
    Leung, Gabriel M.
    [J]. LANCET, 2020, 395 (10233) : 1382 - 1393
  • [10] Leung K, 2017, LANCET INFECT DIS, V17, P339, DOI [10.1016/S1473-3099(16)30465-0, 10.1016/s1473-3099(16)30465-0]
12