Human Immunodeficiency Virus Type 1 Isolates with the Reverse Transcriptase (RT) Mutation Q145M Retain Nucleoside and Nonnucleoside RT Inhibitor Susceptibility

被引：1

作者：

Varghese, Vici

Mitsuya, Yumi

Shahriar, Rajin

Bachmann, Michael H. ^{[2
]}

Fessel, W. Jeffrey ^{[3
]}

Kagan, Ron M. ^{[4
]}

Shafer, Robert W. ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Div Infect Dis, Dept Med,Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[3] Kaiser Permanente Med Care Program No Calif, San Francisco, CA USA

[4] Quest Diagnost, Dept Infect Dis, San Juan Capistrano, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期

关键词：

DRUG-RESISTANCE; PROTEASE; ASSAYS;

D O I：

10.1128/AAC.01593-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Q145M, a mutation in a conserved human immunodeficiency virus type 1 reverse transcriptase (RT) region, was reported to decrease susceptibility to multiple RT inhibitors. We report that Q145M and other Q145 mutations do not emerge with RT inhibitors nor decrease RT inhibitor susceptibility. Q145M should not, therefore, be considered an RT inhibitor resistance mutation.

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页码：2196 / 2198

页数：3

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