Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview

被引：184

作者：

Dhameja, Manoj ^{[1
]}

Gupta, Preeti ^{[1
]}

机构：

[1] Babasaheb Bhimrao Ambedkar Univ, Sch Phys & Decis Sci, Dept Chem, Rae Bareli Rd, Lucknow 226025, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 176卷

关键词：

alpha-Glucosidase inhibitors; Heterocyclic compounds; Structure activity relationship (SAR); Docking study; IN-VITRO EVALUATION; TETRACYCLIC OXINDOLE DERIVATIVES; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; XANTHONE DERIVATIVES; EMERGING SCAFFOLD; 1,2,4-TRIAZINE DERIVATIVES; BENZIMIDAZOLE DERIVATIVES; MULTICOMPONENT SYNTHESIS; MALONAMIDE DERIVATIVES;

D O I：

10.1016/j.ejmech.2019.04.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

alpha-Glucosidase enzyme inhibition is an effective therapeutic decorum in the treatment of type 2 diabetes mellitus. Since 1990, three alpha-glucosidase inhibitors are known to exist clinically, Acarbose, Voglibose and Miglitol. Side effects and long synthetic routes to access them forced the researchers to move their focus to discover simple and small heterocyclic motifs that work as promising alpha-glucosidase inhibitors and may eventually lead to the management of postprandial hyperglycemic condition in T2DM. In this regards, this review deals with recently discovered heterocyclic molecules that have been evaluated to exhibit inhibition of alpha-glucosidase enzyme. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：343 / 377

页数：35

相关论文

共 160 条

[11] Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors [J].

Arshad, Tanzila ;

Khan, Khalid Mohammed ;

Rasool, Najma ;

Salar, Uzma ;

Hussain, Shafqat ;

Tahir, Tehreem ;

Ashraf, Mohammed ;

Wadood, Abdul ;

Riaz, Muhammad ;

Perveen, Shahnaz ;

Taha, Muhammad ;

Ismail, Nor Hadiani .

MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (09) :2058-2069

[12] Synthesis of 1H-1,2,3-triazole derivatives as new α-glucosidase inhibitors and their molecular docking studies [J].

Avula, Satya Kumar ;

Khan, Ajmal ;

Rehman, Najeeb Ur ;

Anwar, Muhammad U. ;

Al-Abri, Zahra ;

Wadood, Abdul ;

Riaz, Muhammad ;

Csuk, Rene ;

Al-Harrasi, Ahmed .

BIOORGANIC CHEMISTRY, 2018, 81 :98-106

[13] Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery [J].

Ayati, Adile ;

Emami, Saeed ;

Asadipour, Ali ;

Shafiee, Abbas ;

Foroumadi, Alireza .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 97 :699-718

[14] Molecular docking and glucosidase inhibition studies of novel N-arylthiazole-2-amines and Ethyl 2-[aryl(thiazol-2-yl)amino]acetates [J].

Babar, Ayesha ;

Yar, Muhammad ;

Tarazi, Hamadeh ;

Duarte, Vera ;

Alshammari, Mohammed B. ;

Gilani, Mazhar Amjad ;

Iqbal, Haffsah ;

Munawwar, Munawwar Ali ;

Alves, Maria J. ;

Khan, Ather Farooq .

MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (12) :3247-3261

[15] 1,3,4-Oxadiazoles: An emerging scaffold to target growth factors, enzymes and kinases as anticancer agents [J].

Bajaj, Shalini ;

Asati, Vivek ;

Singh, Jagadish ;

Roy, Partha Pratim .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 97 :124-141

[16] Synthesis, molecular structure, spectral analysis, and biological activity of new malonamide derivatives as α-glucosidase inhibitors [J].

Barakat, Assem ;

Islam, Mohammad Shahidul ;

Al-Majid, Abdullah Mohammed ;

Soliman, Saied M. ;

Ghabbour, Hazem A. ;

Yousuf, Sammer ;

Choudhary, M. Iqbal ;

Ul-Haq, Zaheer .

JOURNAL OF MOLECULAR STRUCTURE, 2017, 1134 :253-264

[17] Synthesis and structure investigation of novel pyrimidine-2,4,6-trione derivatives of highly potential biological activity as anti-diabetic agent [J].

Barakat, Assem ;

Soliman, Saied M. ;

Al-Majid, Abdullah Mohammed ;

Lotfy, Gehad ;

Ghabbour, Hazem A. ;

Fun, Hoong-Kun ;

Yousuf, Sammer ;

Choudhary, M. Iqbal ;

Wadood, Abdul .

JOURNAL OF MOLECULAR STRUCTURE, 2015, 1098 :365-376

[18] Substituted furopyridinediones as novel inhibitors of α-glucosidase [J].

Bathula, Chandramohan ;

Mamidala, Rajinikanth ;

Thulluri, Chiranjeevi ;

Agarwal, Rahul ;

Jha, Kunal Kumar ;

Munshi, Parthapratim ;

Adepally, Uma ;

Singh, Ashutosh ;

Chary, M. Thirumala ;

Sen, Subhabrata .

RSC ADVANCES, 2015, 5 (110) :90374-90385

[19] Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and α-glucosidase inhibition [J].

Bekircan, Olcay ;

Ulker, Serdar ;

Mentese, Emre .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2015, 30 (06) :1002-1009

[20] An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds [J].

Cascioferro, Stella ;

Parrino, Barbara ;

Spano, Virginia ;

Carbone, Anna ;

Montalbano, Alessandra ;

Barraja, Paola ;

Diana, Patrizia ;

Cirrincione, Girolamo .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 142 :328-375

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