Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview

被引：184
作者：
Dhameja, Manoj [1 ]
Gupta, Preeti [1 ]
机构：
[1] Babasaheb Bhimrao Ambedkar Univ, Sch Phys & Decis Sci, Dept Chem, Rae Bareli Rd, Lucknow 226025, Uttar Pradesh, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 176卷
关键词：
alpha-Glucosidase inhibitors; Heterocyclic compounds; Structure activity relationship (SAR); Docking study; IN-VITRO EVALUATION; TETRACYCLIC OXINDOLE DERIVATIVES; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; XANTHONE DERIVATIVES; EMERGING SCAFFOLD; 1,2,4-TRIAZINE DERIVATIVES; BENZIMIDAZOLE DERIVATIVES; MULTICOMPONENT SYNTHESIS; MALONAMIDE DERIVATIVES;
D O I：
10.1016/j.ejmech.2019.04.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
alpha-Glucosidase enzyme inhibition is an effective therapeutic decorum in the treatment of type 2 diabetes mellitus. Since 1990, three alpha-glucosidase inhibitors are known to exist clinically, Acarbose, Voglibose and Miglitol. Side effects and long synthetic routes to access them forced the researchers to move their focus to discover simple and small heterocyclic motifs that work as promising alpha-glucosidase inhibitors and may eventually lead to the management of postprandial hyperglycemic condition in T2DM. In this regards, this review deals with recently discovered heterocyclic molecules that have been evaluated to exhibit inhibition of alpha-glucosidase enzyme. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：343 / 377
页数：35
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