Propylthiouracil Solubility in Aqueous Solutions of Ethylene Glycol, N,N-Dimethylformamide, N-Methyl-2-pyrrolidone, and Dimethylsulfoxide: Measurement and Thermodynamic Modeling

被引：20

作者：

Yin, Hao ^{[1
]}

Zhao, Hongkun ^{[1
]}

Zhao, Youhua ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2019年 / 64卷 / 06期

关键词：

SOLVENTS; TEMPERATURES; PREDICTION; CONSTANTS; MIXTURES; ETHANOL; DRUGS;

D O I：

10.1021/acs.jced.9b00201

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Solubility values of propylthiouracil dissolved in four neat solvents of N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), dimethylsulfoxide (DMSO), and ethylene glycol (EG) and aqueous cosolvent solutions of DMF, NMP, EG, and DMSO from 293.15 to 333.15 K were determined. The determination process was carried out using the saturation shake-flask method at 101.1 kPa. At the identical temperature and cosolvent composition of DMF, NMP, EG, or DMSO, the solubility of propylthiouracil in mole fraction was maximum in DMSO (DMF) (1) + water (2) systems, and minimum in EG (1) + water (2) systems. Through the vant Hoff-Jouyban-Acree, Jouyban-Acree, and Apelblat-Jouyban-Acree models, the solubility of propylthiouracil was correlated very well, acquiring root-mean-square deviation values that are smaller than 9.75 x 10(-4) and relative average deviation values that are smaller than 3.01%.

引用

页码：2836 / 2842

页数：7

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