LC-MS Guided Isolation of (±)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii

被引：24

作者：

Geng, Chang-An ^{[1
]}

Chen, Xing-Long ^{[1
]}

Zhou, Ning-Jia ^{[1
]}

Chen, Hao ^{[1
]}

Ma, Yun-Bao ^{[1
]}

Huang, Xiao-Yan ^{[1
]}

Zhang, Xue-Mei ^{[1
]}

Chen, Ji-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

基金：

美国国家科学基金会; 中国国家自然科学基金; 中国科学院西部之光基金;

关键词：

ALKALOIDS;

D O I：

10.1021/ol403198d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+/-)-Sweriledugenin A, a pair of novel enantiomeric lactones, were isolated from Swertia leducii under the guidance of LC-MS investigation. The enantiomeric separation was achieved by HPLC on a chiral column. Their structures were determined by extensive NMR spectra, X-ray, and quantum calculations. (+)-Sweriledugenin A and (-)-sweriledugenin A showed activities inhibiting HBV DNA replication with the IC50 values of 36.86 and 26.55 mu M on the HepG 2.2.15 cell line in vitro.

引用

页码：370 / 373

页数：4

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