CHANGES OF THE PHOSPHOLIPID CONTENT AND COMPOSITION IN BRAIN SUBCELLULAR FRACTIONS IN A RAT MODEL OF CEREBRAL ISCHEMIA

被引：0
作者：
Petrova, Emilia [1 ]
Dishkelov, Atanas
Vasileva, Evgenia
机构：
[1] Bulgarian Acad Sci, Inst Expt Morphol, BU-1113 Sofia, Bulgaria
来源：
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2009年 / 62卷 / 03期
关键词：
cerebral ischemia; phospholipids; rat brain; subcellular fractions; FOREBRAIN ISCHEMIA; ACID; LIPIDS;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, we report phospholipid changes in rat brain subcellular fractions in an experimental model of cerebral ischemia. In control rats, the total phospholipid content was the highest in microsomes and the lowest in brain homogenate. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were the most prominent components in all fractions. Cerebral ischemia led to a decrease of total phospholipids in homogenate, nuclei, microsomes and myelin with the largest decrease in homogenate - 8-fold. Synaptosomes and mitochondria showed an increase in phospholipid content - 3.7- and 4-fold, respectively. The individual phospholipids showed specific changes in each subcellular fraction. Nevertheless, after ischemia PC and PE were still the major components in all fractions.
引用
收藏
页码：373 / 378
页数：6
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