Glutaminolysis gets the spotlight in cancer

被引：4

作者：

Herranz, Daniel ^{[1
]}

机构：

[1] Columbia Univ, Inst Canc Genet, New York, NY 10027 USA

来源：

ONCOTARGET | 2017年 / 8卷 / 07期

关键词：

glutaminolysis; glutamine; AML; cancer metabolism; targeted therapies; ACUTE MYELOID-LEUKEMIA; INHIBITION;

D O I：

10.18632/oncotarget.14384

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：10761 / 10762

页数：2

共 8 条

[1] From Krebs to clinic: glutamine metabolism to cancer therapy [J].

Altman, Brian J. ;

Stine, Zachary E. ;

Dang, Chi V. .

NATURE REVIEWS CANCER, 2016, 16 (10) :619-634

[2] Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations [J].

Emadi, Ashkan ;

Ju, Sung Ah ;

Tsukamoto, Takashi ;

Fathi, Amir T. ;

Minden, Mark D. ;

Dang, Chi V. .

EXPERIMENTAL HEMATOLOGY, 2014, 42 (04) :247-251

[3] Glutamine and cancer: cell biology, physiology, and clinical opportunities [J].

Hensley, Christopher T. ;

Wasti, Ajla T. ;

DeBerardinis, Ralph J. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (09) :3678-3684

[4] Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia [J].

Herranz, Daniel ;

Ambesi-Impiombato, Alberto ;

Sudderth, Jessica ;

Sanchez-Martin, Marta ;

Belver, Laura ;

Tosello, Valeria ;

Xu, Luyao ;

Wendorff, Agnieszka A. ;

Castillo, Mireia ;

Haydu, J. Erika ;

Marquez, Javier ;

Mates, Jose M. ;

Kung, Andrew L. ;

Rayport, Stephen ;

Cordon-Cardo, Carlos ;

DeBerardinis, Ralph J. ;

Ferrando, Adolfo A. .

NATURE MEDICINE, 2015, 21 (10) :1182-+

[5] Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition [J].

Jacque, Nathalie ;

Ronchetti, Anne Marie ;

Larrue, Clement ;

Meunier, Godelieve ;

Birsen, Rudy ;

Willems, Lise ;

Saland, Estelle ;

Decroocq, Justine ;

Maciel, Thiago Trovati ;

Lambert, Mireille ;

Poulain, Laury ;

Sujobert, Pierre ;

Joseph, Laure ;

Chapuis, Nicolas ;

Lacombe, Catherine ;

Moura, Ivan Cruz ;

Demo, Susan ;

Sarry, Jean Emmanuel ;

Recher, Christian ;

Mayeux, Patrick ;

Tamburini, Jerome ;

Bouscary, Didier .

BLOOD, 2015, 126 (11) :1346-1356

[6] Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes [J].

Matre, Polina ;

Velez, Juliana ;

Jacamo, Rodrigo ;

Qi, Yuan ;

Su, Xiaoping ;

Cai, Tianyu ;

Chan, Steven M. ;

Lodi, Alessia ;

Sweeney, Shannon R. ;

Ma, Helen ;

Davis, Richard Eric ;

Baran, Natalia ;

Haferlach, Torsten ;

Su, Xiaohua ;

Flores, Elsa Renee ;

Gonzalez, Doriann ;

Konoplev, Sergej ;

Samudio, Ismael ;

DiNardo, Courtney ;

Majeti, Ravi ;

Schimmer, Aaron D. ;

Li, Weiqun ;

Wang, Taotao ;

Tiziani, Stefano ;

Konopleva, Marina .

ONCOTARGET, 2016, 7 (48) :79708-79721

[7] Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia [J].

Willems, Lise ;

Jacque, Nathalie ;

Jacquel, Arnaud ;

Neveux, Nathalie ;

Maciel, Thiago Trovati ;

Lambert, Mireille ;

Schmitt, Alain ;

Poulain, Laury ;

Green, Alexa S. ;

Uzunov, Madalina ;

Kosmider, Olivier ;

Radford-Weiss, Isabelle ;

Moura, Ivan Cruz ;

Auberger, Patrick ;

Ifrah, Norbert ;

Bardet, Valerie ;

Chapuis, Nicolas ;

Lacombe, Catherine ;

Mayeux, Patrick ;

Tamburini, Jerome ;

Bouscary, Didier .

BLOOD, 2013, 122 (20) :3521-3532

[8] Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis [J].

Xiang, Yan ;

Stine, Zachary E. ;

Xia, Jinsong ;

Lu, Yunqi ;

O'Connor, Roddy S. ;

Altman, Brian J. ;

Hsieh, Annie L. ;

Gouw, Arvin M. ;

Thomas, Ajit G. ;

Gao, Ping ;

Sun, Linchong ;

Song, Libing ;

Yan, Benedict ;

Slusher, Barbara S. ;

Zhuo, Jingli ;

Ooi, London L. ;

Lee, Caroline G. L. ;

Mancuso, Anthony ;

McCallion, Andrew S. ;

Le, Anne ;

Milone, Michael C. ;

Rayport, Stephen ;

Felsher, Dean W. ;

Dang, Chi V. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (06) :2293-2306

← 1 →