Basic fibroblast growth factor promotes nerve regeneration in a C--ion-implanted silicon chamber

被引：15

作者：

Ikeguchi, Ryosuke

Kakinoki, Ryosuke

Matsumoto, Taiichi

Yamakawa, Tomoyuki

Nakayama, Ken

Morimoto, Yoshihide

Tsuji, Hiroshi

Ishikawa, Junzo

Nakamura, Takashi

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Orthoped Surg, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Elect, Nishigyo Ku, Kyoto 6158510, Japan

来源：

BRAIN RESEARCH | 2006年 / 1090卷

关键词：

peripheral nerve regeneration; tubulation; carbon ion implantation; biocompatibility; basic fibroblast growth factor;

D O I：

10.1016/j.brainres.2006.03.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We reported previously that a silicone tube whose inner surface has been implanted with negatively charged carbon ions (C-) enables a nerve to regenerate across a 15-mm inter-stump gap. In this study, we investigated whether a C--ion-implanted tube pretreated with basic fibroblast growth factor promotes peripheral nerve regeneration. The C--ion-implanted tube significantly accelerated nerve regeneration, and this effect was enhanced by basic fibroblast growth factor.

引用

页码：51 / 57

页数：7

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