Toll-Like Receptors and Ischemic Brain Injury

被引：108

作者：

Gesuete, Raffaella ^{[1
]}

Kohama, Steven G. ^{[2
]}

Stenzel-Poore, Mary P. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97239 USA

[2] Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2014年 / 73卷 / 05期

关键词：

Cerebral ischemia; Ischemic brain injury; Preconditioning; Stroke; Toll-like receptors; PRECONDITIONING PROTECTS; CEREBRAL-ISCHEMIA; STROKE; NEUROPROTECTION; TOLL-LIKE-RECEPTOR-4; INFLAMMATION; RECOGNITION; MECHANISMS; EXPRESSION; TNF;

D O I：

10.1097/NEN.0000000000000068

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Toll-like receptors (TLRs) are master regulators of innate immunity and play an integral role in the activation of inflammatory response during infections. In addition, TLRs influence the body's response to numerous forms of injury. Recent data have shown that TLRs play a modulating role in ischemic brain damage after stroke. Interestingly, their stimulation before ischemia induces a tolerant state that is neuroprotective. This phenomenon, referred to as TLR preconditioning, is the result of the reprogramming of TLR response to ischemic injury. This review addresses the role of TLRs in brain ischemia and the activation of endogenous neuroprotective pathways in the setting of preconditioning. We highlight the protective role of interferon-related response and the potential site of action for TLR preconditioning involving the blood-brain barrier. Pharmacologic modulation of TLR activation to promote protection against stroke is a promising approach for the development of prophylactic and immediate therapies targeting ischemic brain injury.

引用

页码：378 / 386

页数：9

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