Extracellular Vesicles in Epstein-Barr Virus Pathogenesis

被引：23

作者：

Cone, Allaura S. ^{[1
]}

York, Sara B. ^{[1
]}

Meckes, David G., Jr. ^{[1
]}

机构：

[1] Florida State Univ, Dept Biomed Sci, Coll Med, Tallahassee, FL 32306 USA

来源：

CURRENT CLINICAL MICROBIOLOGY REPORTS | 2019年 / 6卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Epstein-Barr virus; Extracellular vesicles; Cancer; Exosomes; Autoimmune; Diagnostic; CELL-DERIVED EXOSOMES; SMALL RNA 1; NASOPHARYNGEAL CARCINOMA; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; VIRAL MIRNAS; LMP1; DIFFERENTIATION; DELIVERY; MICROVESICLES;

D O I：

10.1007/s40588-019-00123-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Purpose of Review Epstein-Barr virus (EBV) is a known determinant for numerous malignancies and may contribute to autoimmune diseases. The underlining mechanisms behind EBV pathologies are not completely understood. Recently, extracellular vesicles (EVs) released from infected cells have been found to produce profound effects on cellular microenvironments. Therefore, in this review, we sought to critically evaluate the roles of EVs in EBV pathogenesis and assess their potential therapeutic and diagnostic utility. Recent Findings EBV-altered EVs are capable of activating signaling cascades and phenotypic changes in recipient cells through the transfer of viral proteins and RNAs. Moreover, several EV-associated microRNAs have encouraging prognostic or diagnostic potential in EBV-associated cancers. Current evidence suggests that EBV-modified EVs affect viral pathogenesis and cancer progression. However, further research is needed to investigate the direct role of both viral and host products on recipient cells and the mechanisms driving viral protein and RNA EV packaging and content modification.

引用

页码：121 / 131

页数：11

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