Gene therapy for T-cell immunodeficiencies

被引：0

作者：

Kohn, DB

Weinberg, KI

Parkman, R

机构：

[1] Childrens Hosp Los Angeles, Div Res Immunol Bone Marrow Transplantat, Los Angeles, CA 90027 USA

[2] Univ So Calif, Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[3] Univ So Calif, Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2000年 / 20卷 / 01期

关键词：

D O I：

10.1016/S0889-8561(05)70143-0

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

As the field of human gene therapy has developed over the past 15 years, T-cell immunodeficiencies have been a frequent target of investigation. The first of these was ADA deficiency (i.e., SCID) because of the availability of the responsible gene. As the genes responsible for several of the other T-cell immunodeficiencies have been identified and cloned, these deficiencies also have been investigated in preclinical studies and are now the subject of clinical trials. This article reviews the work that has been performed to date and future directions.

引用

页码：221 / +

页数：17

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