Use of capillary electrophoresis for the determination of impurities in preparations of fluorine-18 labelled PET radiopharmaceuticals

被引：7

作者：

Antuganov, Dmitrii ^{[1
]}

Antuganova, Yulija ^{[1
]}

Zykova, Tatiana ^{[1
]}

Krasikova, Raisa ^{[2
,3
]}

机构：

[1] Natl Almazov Med Res Ctr, PET Ctr, 2 Akkuratova St, St Petersburg 197341, Russia

[2] Russian Acad Sci, NP Bechtereva Inst Human Brain, Lab Radiochem, 9 Ak Pavlova St, St Petersburg 197376, Russia

[3] St Petersburg State Univ, Inst Chem, Univ Skaya Emb 13B, St Petersburg 199034, Russia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2019年 / 173卷

关键词：

Capillary electrophoresis; Positron emission tomography; Radiopharmaceuticals; Simultaneous determination; Quality control; COPPER-MEDIATED RADIOFLUORINATION; AUTOMATED SYNTHESIS; CHEMICAL IDENTITY; SEPARATION; ONCOLOGY; PURITY;

D O I：

10.1016/j.jpba.2019.05.016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Fluorine-18 labelled radiotracers are the most common diagnostic agents employed in positron emission tomography (PET). Despite well-established quality control (QC) procedures, introduction of new synthetic methods demands continuous development of analytical methodology. Here we propose capillary electrophoresis (CE) as a simple, fast and cost-efficient analytical method, allowing for the evaluation of potentially toxic impurities, including transition metals, in the formulated preparations. Method developed was applied in routine QC procedures for several clinically relevant radiotracers. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：68 / 74

页数：7

共 30 条

[1]

[Anonymous], 2019, ICH GUIDELINE ELEMEN

[2]

[Anonymous], 2018, IAEATECDOC1856, P133

[3]

[Anonymous], 2019, EUROPEAN PHARMACOPOE, V3, P1146

[4]

[Anonymous], 2019, EUROPEAN PHARMACOPOE, V3, P1141

[5] Modification of Automatic Synthesis of [F-18]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module [J].

Antuganov, D. O. ;

Ryzhkova, D. V. ;

Zykova, T. A. ;

Timofeev, V. V. ;

Antuganova, Yu. O. ;

Timofeeva, K. Yu. ;

Samburov, O. P. ;

Zykov, M. P. .

RADIOCHEMISTRY, 2018, 60 (01) :45-50

[6] Synthesis of [F-18]-L-DOPA Radiopharmaceutical on a Modified GE TracerLAB Fx F-E Platform [J].

Antuganov, D. O. ;

Zykov, M. P. ;

Ryzhkova, D. V. ;

Zykova, T. A. ;

Vinal'ev, A. A. ;

Antuganova, Yu. O. ;

Samburov, O. P. .

RADIOCHEMISTRY, 2016, 58 (06) :649-653

[7] Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates [J].

Antuganov, Dmitrii ;

Zykov, Michail ;

Timofeev, Vasilii ;

Timofeeva, Ksenija ;

Antuganova, Yulija ;

Orlovskaya, Victoriya ;

Fedorova, Olga ;

Krasikova, Raisa .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 2019 (05) :918-922

[8] Effect of Pyridine Addition on the Efficiency of Copper-Mediated Radiofluorination of Aryl Pinacol Boronates [J].

Antuganov, Dmitrii ;

Zykov, Michail ;

Timofeeva, Ksenija ;

Antuganova, Yulija ;

Orlovskaya, Victoriya ;

Krasikova, Raisa .

CHEMISTRYSELECT, 2017, 2 (26) :7909-7912

[9] The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis [J].

Cheung, Shilin ;

Ly, Jimmy ;

Lazari, Mark ;

Sadeghi, Saman ;

Keng, Pei Yuin ;

van Dam, R. Michael .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 94 :12-18

[10] Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences [J].

Coenen, H. H. ;

Elsinga, P. H. ;

Iwata, R. ;

Kilbourn, M. R. ;

Pillai, M. R. A. ;

Rajan, M. G. R. ;

Wagner, H. N., Jr. ;

Zaknun, J. J. .

NUCLEAR MEDICINE AND BIOLOGY, 2010, 37 (07) :727-740

← 1 2 3 →