Synthesis of novel, azasugar-modified anthraquinone derivatives and their cytotoxicity

被引：6

作者：

Zhang, Ping-Zhu ^{[1
,2
]}

Yang, Hai-Long ^{[1
]}

Li, Cui-Cui ^{[1
]}

Xia, Zhi-Chao ^{[1
]}

Wang, Xiao-Man ^{[3
]}

Wei, Hua ^{[1
]}

Rong, Rui-Xue ^{[3
]}

Cao, Zhi-Ran ^{[3
]}

Wang, Ke-Rang ^{[1
,2
]}

Chen, Hua ^{[1
,2
]}

Li, Xiao-Liu ^{[1
,2
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China

[2] Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China

[3] Hebei Univ, Sch Basic Med Sci, Dept Immunol, Baoding 071002, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Anthraquinone; Azasugar; Cytotoxic activity; G-QUADRUPLEX LIGANDS; HUMAN TELOMERASE; INHIBITORS; DESIGN; AGENTS; DNA;

D O I：

10.1016/j.cclet.2014.05.029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug (Cisplatin). (C) 2014 Xiao-Liu Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1057 / 1059

页数：3

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