Synthesis of novel, azasugar-modified anthraquinone derivatives and their cytotoxicity

被引：6
|
作者：
Zhang, Ping-Zhu [1 ,2 ]
Yang, Hai-Long [1 ]
Li, Cui-Cui [1 ]
Xia, Zhi-Chao [1 ]
Wang, Xiao-Man [3 ]
Wei, Hua [1 ]
Rong, Rui-Xue [3 ]
Cao, Zhi-Ran [3 ]
Wang, Ke-Rang [1 ,2 ]
Chen, Hua [1 ,2 ]
Li, Xiao-Liu [1 ,2 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China
[2] Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
[3] Hebei Univ, Sch Basic Med Sci, Dept Immunol, Baoding 071002, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Anthraquinone; Azasugar; Cytotoxic activity; G-QUADRUPLEX LIGANDS; HUMAN TELOMERASE; INHIBITORS; DESIGN; AGENTS; DNA;
D O I：
10.1016/j.cclet.2014.05.029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug (Cisplatin). (C) 2014 Xiao-Liu Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1057 / 1059
页数：3
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