The phenolic acids from the plant of Salvia miltiorrhiza

被引：7

作者：

Jiang, Jian-Shuang ^{[1
]}

Gu, Quan-chang ^{[1
]}

Feng, Zi-Ming ^{[1
]}

Yuan, Xiang ^{[1
]}

Zhang, Xu ^{[1
]}

Zhang, Pei-Cheng ^{[1
]}

Yang, Ya-Nan ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2022年 / 159卷

关键词：

Salvia miltiorrhiza; Isolation and purification; Phenolic acids; Structural elucidation; Neuroprotective activity; ANTIOXIDANT ACTIVITIES; EXTRACT; BUNGE;

D O I：

10.1016/j.fitote.2022.105180

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new phenolic acids, 7, 8-epiblechnic acid (1), 8-epiblechnic acid 9-ehthyl-9 & PRIME;-methyl ester (2), 9 & PRIME;-ehyl-isolithospermate (3), 9 & DPRIME;-methyl-isolithospermate (4), 9 & PRIME;-ethyl-9 & DPRIME;-methyl-isolithospermate (5), 9 & PRIME;, 9 & DPRIME;-dimethyl-isolithospermate (6), sebesteniod E (7), were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by detailed spectroscopic means including UV, IR, HRESIMS, and NMR data spectra. The bioactive assays of compounds 1-7 against neuroprotection activities were determined. The results suggested that compound 4 exhibited a moderate glutamate-induced neuroprotective activity and the cell survival rate was 24.0% (10-5 mol/L), while compound 2 showed weak activity (survival rate: 7.58%, 10-5 mol/L), using PHPB (survival rate: 7.56%, 10-5 mol/L) as positive control.

引用

页数：6

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