Silver-catalyzed dynamic systemic resolution of α-iminonitriles in a 1,3-dipolar cycloaddition process

被引：29
|
作者：
Hu, Lei [1 ]
Ramstrom, Olof [1 ]
机构：
[1] KTH Royal Inst Technol, Dept Chem, Stockholm, Sweden
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 29期
基金：
瑞典研究理事会;
关键词：
COMBINATORIAL RESOLUTION; ASYMMETRIC-SYNTHESIS; INHIBITORS; INDOLIZIDINE; CHEMISTRY; LIBRARIES;
D O I：
10.1039/c4cc00944d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A dynamic azomethine ylide system was established using Sc(OTf)(3) and Ag/Taniaphos as catalysts. The system was subsequently kinetically resolved in a tandem 1,3-dipolar cycloaddition process where the silver complex acted as both a reaction catalyst and an external selector, resulting in the formation of an exclusive pyrrolidine product in good yield and enantiopurity.
引用
收藏
页码：3792 / 3794
页数：3
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