Novel Benzil and Isoflavone Derivatives from Millettia dielsiana

The analysis of vine stem extract from Millettia dielsiana Harms yielded a novel benzil (1) and five new prenylated isoflavones (2-6) together with three known isoflavones (7-10) and one known flavone (11), and their structures were elucidated on the basis of chemical and spectral analysis. The absolute configuration of the 3 '',4 '' diols in 6 was determined by observing the CD induced after addition of dimolybdenum tetraacetate in DMSO solution (Snatzke's method). Some isolates were tested for their anti-inflammatory and antithrombase activities and cytotoxicities. Compound 2, barbigerone, and genistein showed significant anti-inflammatory activity, with inhibitory ratios 59.1%, 59.5%, and 58.5%, respectively, at 10 mu M, while compound 4 exhibited moderate cytotoxicity.