Curcumin and isonicotinic acid hydrazide functionalized gold nanoparticles for selective anticancer action

被引：28

作者：

Umapathi, Akhela ^{[1
]}

Navya, P. N. ^{[2
]}

Madhyastha, Harishkumar ^{[3
]}

Singh, Mandeep ^{[4
]}

Madhyastha, Radha ^{[3
]}

Maruyama, Masugi ^{[3
]}

Daima, Hemant Kumar ^{[1
]}

机构：

[1] Amity Univ Rajasthan, Amity Ctr Nanobiotechnol & Nanomed ACNN, Amity Inst Biotechnol, NH-11C, Jaipur 303002, Rajasthan, India

[2] Bannari Amman Inst Technol, Dept Biotechnol, Sathyamangalam, Erode, India

[3] Univ Miyazaki, Fac Med, Dept Appl Physiol, Miyazaki 8891692, Japan

[4] RMIT Univ, Sch Sci, Melbourne, Vic 3000, Australia

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2020年 / 607卷

关键词：

Gold nanoparticles; Curcumin; Isonicotinic acid hydrazide; Lung carcinoma; Anticancer; Cisplatin;

D O I：

10.1016/j.colsurfa.2020.125484

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Besides physicochemical properties, careful design of biomolecular surface corona can dictate therapeutic potential of nanoparticles. Therefore, we demonstrate a new approach to improve the anticancer potential of gold nanoparticles (AuNPs) by developing a strong corona of curcumin and isonicotinic acid hydrazide (INH) around them. Here, cur cumin reduced AuNPs(Cur) are surface-functionalized with biologically active INH (AuNPs(Cur@INH)). Our investigations on human lung squamous carcinoma (LK-2) and human lung fibroblast (TIG-120) cells indicate selective toxicity of functionalized nanoparticles. Conjugation of curcumin and INH on the surface of AuNPs induced anticancer action through reactive oxygen species (ROS) generation. The further extension of this study revealed apoptosis and morphological changes in LK-2 and TIG-120 cells, respectively. Moreover, the anticancer potential of these nanoparticles is compared with standard cisplatin. The outcomes of the work determine that the facile functional surfaces on nano particles can be important in controlling the biological activities of nanoparticles.

引用

页数：10

共 51 条

[1] Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery [J].