X-ray Inducible Luminescence and Singlet Oxygen Sensitization by an Octahedral Molybdenum Cluster Compound: A New Class of Nanoscintillators

被引:108
作者
Kirakci, Kaplan [1 ]
Kubat, Pavel [2 ]
Fejfarova, Karla [3 ]
Martincik, Jiri [3 ,4 ]
Nikl, Martin [3 ]
Lang, Kamil [1 ]
机构
[1] Acad Sci Czech Republ, Inst Inorgan Chem, Vvi, Husinec Rez 1001, CZ-25068 Rez, Czech Republic
[2] Acad Sci Czech Republ, J Heyrovsky Inst Phys Chem, Vvi, Dolejskova 3, CR-18223 Prague 8, Czech Republic
[3] Acad Sci Czech Republ, Inst Phys, Vvi, Cukrovarnicka 10-112, Prague 16200 6, Czech Republic
[4] Czech Tech Univ, Fac Nucl Sci & Phys Engn, Brehova 7, CR-11519 Prague 1, Czech Republic
关键词
PHOTODYNAMIC THERAPY; NANOPARTICLES; COMPLEXES; NANOMATERIALS; POLYSTYRENE; RADIATION; POLYMER;
D O I
10.1021/acs.inorgchem.5b02282
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Newly synthesized octahedral molybdenum cluster compound (n-Bu4N)(2)[Mo6I8(OOC-1-adamantane)(6)] revealed uncharted features applicable for the development of X-ray inducible luminescent materials and sensitizers of singlet oxygen, O-2((1)). The compound exhibits a red-NIR luminescence in the solid state and in solution (e.g., quantum yield of 0.76 in tetrahydrofuran) upon excitation by UV-vis light. The luminescence originating from the excited triplet states is quenched by molecular oxygen to produce O-2(g) with a high quantum yield. Irradiation of the compound by X-rays generated a radioluminescence with the same emission spectrum as that obtained by UV-vis excitation. It proves the formation of the same excited triplet states regardless of the excitation source. By virtue of the described behavior, the compound is suggested as an efficient sensitizer of O-2(g) upon X-ray excitation. The luminescence and radioluminescence properties were maintained upon embedding the compound in polystyrene films. In addition, polystyrene induced an enhancement of the radioluminescence intensity via energy transfer from the scintillating polymeric matrix. Sulfonated polystyrene nanofibers were used for the preparation of nanoparticles which form stable dispersions in water, while keeping intact the luminescence properties of the embedded compound over a long time period. Due to their small size and high oxygen diffusivity, these nanoparticles are suitable carriers of sensitizers of O-2(g). The presented results define a new class of nanoscintillators with promising properties for X-ray inducible photodynamic therapy.
引用
收藏
页码:803 / 809
页数:7
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