Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

被引：132

作者：

Holt, Kathryn E. ^{[1
]}

McAdam, Paul ^{[1
]}

Phan Vuong Khac Thai ^{[2
]}

Nguyen Thuy Thuong Thuong ^{[3
]}

Dang Thi Minh Ha ^{[2
]}

Nguyen Ngoc Lan ^{[2
]}

Nguyen Huu Lan ^{[2
]}

Nguyen Thi Quynh Nhu ^{[3
]}

Hoang Thanh Hai ^{[3
]}

Vu Thi Ngoc Ha ^{[3
]}

Thwaites, Guy ^{[3
,4
]}

Edwards, David J. ^{[1
]}

Nath, Artika P. ^{[5
,6
]}

Pham, Kym ^{[7
]}

Ascher, David B. ^{[1
]}

Farrar, Jeremy ^{[3
,4
]}

Khor, Chiea Chuen ^{[8
,9
]}

Teo, Yik Ying ^{[10
,11
]}

Inouye, Michael ^{[6
,7
,12
]}

Caws, Maxine ^{[13
,14
]}

Dunstan, Sarah J. ^{[15
]}

机构：

[1] Univ Melbourne, Bio Mol Sci & Biotechnol Inst 21, Dept Biochem & Mol Biol, Parkville, Vic, Australia

[2] Pham Ngoc Thach Hosp TB & Lung Dis, Ho Chi Minh City, Vietnam

[3] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam

[4] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England

[5] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic, Australia

[6] Baker Heart & Diabet Inst, Syst Genom Lab, Melbourne, Vic, Australia

[7] Univ Melbourne, Dept Clin Pathol, Parkville, Vic, Australia

[8] Genome Inst Singapore, Singapore, Singapore

[9] Singapore Eye Res Inst, Singapore, Singapore

[10] Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore, Singapore

[11] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[12] Univ Cambridge, Strangeways Res Labs, Dept Publ Hlth & Primary Care, Cambridge, England

[13] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside, England

[14] Birat Nepal Med Trust, Kathmandu, Nepal

[15] Univ Melbourne, Peter Doherty Inst Infect & Immun, Parkville, Vic, Australia

来源：

NATURE GENETICS | 2018年 / 50卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

DRUG-RESISTANCE; LYMPHATIC EXPOSURE; PROTEIN STABILITY; GENETIC-DISEASE; MUTATIONS; GENOTYPE; EVOLUTION; VACCINE; SERVER; IDENTIFICATION;

D O I：

10.1038/s41588-018-0117-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data identify an underlying burden of disease caused by the endemic Mtb lineage 1 associated with the activation of long-term latent infection, and a threefold higher burden associated with the more recently introduced Beijing lineage and lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than the endemic lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify an alteration in the ESX-5 type VII-secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations.

引用

页码：849 / +

页数：14

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