Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats

被引：62

作者：

Zhu, CB ^{[1
]}

Cao, XD ^{[1
]}

Xu, SF ^{[1
]}

Wu, GC ^{[1
]}

机构：

[1] SHANGHAI MED UNIV,DEPT NEUROBIOL,NATL KEY LAB MED NEUROBIOL,SHANGHAI 200032,PEOPLES R CHINA

来源：

NEUROSCIENCE LETTERS | 1997年 / 235卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

orphanin FQ; formalin pain; morphine analgesia;

D O I：

10.1016/S0304-3940(97)00704-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to observe the effect of orphanin FQ (OFQ, also known as 'nociceptin'), a newly-discovered neuropeptide, on pain behavior and morphine analgesia evaluated by formalin test in rats. It was found that intracerebroventricular (i.c.v.) injection of 0.1 mu g OFQ had no effect on formalin-induced pain behavior; but 1, 5, 10 or 20 mu g OFQ produced prolonged lifting, licking, biting or shaking of the affected paw with higher pain scoring in dose dependent manner. Repeated i.c.v. injection of antisense oligonucleotide (ASO) complementary to OFQ receptor but not mismatch oligonucleotide (MSG) resulted in the decrease of pain behavior; in such circumstances, OFQ showed no enhancing effect on formalin nociception. OFQ (0.1 or 1 mu g, i.c.v.) significantly attenuated morphine analgesia and ASO could validly antagonize the effect of it. Pretreatment with MSO had no such effect. The present results suggest that OFQ enhances the pain behavior of rat and antagonizes morphine analgesia in formalin test. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：37 / 40

页数：4

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