Metabolic syndrome following liver transplantation in nonalcoholic steatohepatitis

被引：14

作者：

Spiritos, Zachary ^{[1
]}

Abdelmalek, Manal F. ^{[1
]}

机构：

[1] Duke Univ, Div Gastroenterol & Hepatol, Durham, NC USA

来源：

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY | 2021年 / 6卷

关键词：

Cardiovascular disease (CVD); diabetes mellitus; dyslipidemia; hypertension; immunosuppression; obesity; nonalcoholic fatty liver disease (NAFLD); transplant outcomes; ONSET DIABETES-MELLITUS; LONG-TERM OUTCOMES; CARDIOVASCULAR RISK; IMMUNOSUPPRESSIVE REGIMEN; HEPATITIS-C; DISEASE; ASSOCIATION; PREVALENCE; RECIPIENTS; PATIENT;

D O I：

10.21037/tgh.2020.02.07

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Metabolic syndrome is a major clinical disorder involving metabolic dysregulation characterized clinically with features of central obesity, insulin resistance (IR), type 2 diabetes, hypertension, and dyslipidemia. Metabolic syndrome is strongly associated with the rising prevalence nonalcoholic steatohepatitis, a leading indication for orthotopic liver transplantation in the Western world. The presence or recurrence of metabolic syndrome following liver transplantation can contribute to the development and recurrence of nonalcoholic fatty liver disease (NAFLD) in the liver allograft. In this review, we discuss the endogenous and exogenous drivers of post-transplant metabolic syndrome, role of chronic immunosuppression, and the prevalence and clinical significant of post-transplant metabolic syndrome on nonalcoholic steatohepatitis.

引用

页数：11

共 61 条

[11] Transplanted liver: Consequences of denervation for liver functions [J].

Colle, I ;

Van Vlierberghe, H ;

Troisi, R ;

De Hemptinne, B .

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY, 2004, 280A (01) :924-931

[12] Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis [J].

Contos, MJ ;

Cales, W ;

Sterling, RK ;

Luketic, VA ;

Shiffman, ML ;

Mills, AS ;

Fisher, RA ;

Ham, J ;

Sanyal, AJ .

LIVER TRANSPLANTATION, 2001, 7 (04) :363-373

[13] Patient survival after renal transplantation III: The effects of statins [J].

Cosio, FG ;

Pesavento, TE ;

Pelletier, RP ;

Henry, M ;

Ferguson, RM ;

Kim, S ;

Lemeshow, S .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 40 (03) :638-643

[14] Prospective study of liver transplant recipients with HCV infection: Evidence for a causal relationship between HCV and insulin resistance [J].

Delgado-Borrego, Aymin ;

Liu, Yun-Sheen ;

Jordan, Sergio H. ;

Agrawal, Saurabh ;

Zhang, Hui ;

Christofi, Marielle ;

Casson, Deborah ;

Cosimi, Benedict ;

Chung, Raymond T. .

LIVER TRANSPLANTATION, 2008, 14 (02) :193-201

[15] Liver Transplantation and Bariatric Surgery: Timing and Outcomes [J].

Diwan, Tayyab S. ;

Rice, Teresa C. ;

Heimbach, Julie K. ;

Schauer, Daniel P. .

LIVER TRANSPLANTATION, 2018, 24 (09) :1280-1287

[16] Prevalence of the metabolic syndrome among US adults - Findings from the Third National Health and Nutrition Examination Survey [J].

Ford, ES ;

Giles, WH ;

Dietz, WH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (03) :356-359

[17] 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines [J].

Goff, David C., Jr. ;

Lloyd-Jones, Donald M. ;

Bennett, Glen ;

Coady, Sean ;

D'Agostino, Ralph B., Sr. ;

Gibbons, Raymond ;

Greenland, Philip ;

Lackland, Daniel T. ;

Levy, Daniel ;

O'Donnell, Christopher J. ;

Robinson, Jennifer G. ;

Schwartz, J. Sanford ;

Shero, Susan T. ;

Smith, Sidney C., Jr. ;

Sorlie, Paul ;

Stone, Neil J. ;

Wilson, Peter W. F. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (25) :2935-2959

[18] Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation [J].

Goldberg, David ;

Ditah, Ivo C. ;

Saeian, Kia ;

Lalehzari, Mona ;

Aronsohn, Andrew ;

Gorospe, Emmanuel C. ;

Charlton, Michael .

GASTROENTEROLOGY, 2017, 152 (05) :1090-+

[19] The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation [J].

Hanouneh, Ibrahim A. ;

Feldstein, Ariel E. ;

McCullough, Arthur J. ;

Miller, Charles ;

Aucejo, Federico ;

Yerian, Lisa ;

Lopez, Rocio ;

Zein, Nizar N. .

LIVER TRANSPLANTATION, 2008, 14 (09) :1287-1293

[20] New onset diabetes mellitus in patients receiving calcineurin inhibitors: A systematic review and meta-analysis [J].

Heisel, O ;

Heisel, R ;

Balshaw, R ;

Keown, P .

AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (04) :583-595

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