Gender differences in the presentation of dysphonia related to laryngopharyngeal reflux disease: a case-control study

被引:16
作者
Lechien, Jerome R. [1 ,2 ,3 ,4 ]
Huet, Kathy [2 ]
Khalife, Mohamad [3 ]
Fourneau, Anne-Francoise [3 ]
Finck, Camille [5 ]
Delvaux, Veronique [2 ]
Piccaluga, Myriam [2 ]
Harmegnies, Bernard [2 ]
Saussez, Sven [1 ,3 ,4 ]
机构
[1] Univ Mons UMons, UMONS Res Inst Hlth Sci & Technol, Lab Anat & Cell Biol, Fac Med, Ave Champ Mars 6, B-7000 Mons, Belgium
[2] Univ Mons UMons, Res Inst Language Sci & Technol, Lab Phonet, Fac Psychol, Mons, Belgium
[3] EpiCURA Hosp, UMONS EpiCURA Res Plateform Baudour, Dept Otorhinolaryngol & Head & Neck Surg, Baudour, Belgium
[4] CHU Bruxelles, CHU St Pierre, Dept Otorhinolaryngol & Head & Neck Surg, Brussels, Belgium
[5] CHU Liege, Dept Otorhinolaryngol & Head & Neck Surg, Liege, Belgium
关键词
Laryngopharyngeal; Reflux; Laryngitis; Voice; VOCAL FOLD LESIONS; ACOUSTIC PARAMETERS; VOICE; SYMPTOMS; AGE; RELIABILITY; LARYNGITIS; MANAGEMENT; DISORDERS; DIAGNOSIS;
D O I
10.1007/s00405-018-4951-2
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
To investigate the voice quality impairments in patients with laryngopharyngeal reflux (LPR) according to the gender. Controlled multi-center study. 80 LPR patients (40 males and 40 females) with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were included and clinically compared according to gender. To be considered as LPR patients, subjects responded to an empiric therapeutic trial based on pantoprazole intake and diet recommendations for 3 months or had positive pH/Impedance metry. Voice Handicap Index (VHI); Short Form Healthy Survey 36 (SF36), blinded Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI); aerodynamic and acoustic measurements were assessed in all patients and compared with 80 healthy controls (40 males and 40 females) according to gender. The most common reasons for the consultation were, respectively, globus sensation in males (22.5%) and dysphonia (27.5%) in female who complained more of breathing difficulties and choking episodes related to LPR than males (p = 0.024). From a quality of life standpoint, female had increased significant impact of LPR disease on vitality and mental health than male. Compared to healthy subjects, both LPR male and female patients had stronger values of G, R, B, S, I, VHI, percent jitter, percent shimmer, and soft palate index than controls. In addition, LPR female had stronger values of lowest fundamental frequency and all aerodynamic measurements than controls. As showed in many other laryngeal conditions, voice quality of female could be more impaired by LPR than male. Some anatomical, histological and functional factors can be suspected and need additional future researches.
引用
收藏
页码:1513 / 1524
页数:12
相关论文
共 46 条
  • [1] Impact of Laryngeal Findings on Acoustic Parameters of Patients with Laryngopharyngeal Reflux
    Akyildiz, Serdar
    Ogut, Fatih
    Varis, Ahmet
    Kirazli, Tayfun
    Bor, Serhat
    [J]. ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY, 2012, 74 (04): : 215 - 219
  • [2] [Anonymous], 2008, ONLINE J HLTH ALLIED
  • [3] Diagnosis of laryngopharyngeal reflux disease with digital imaging
    Beaver, ME
    Stasney, CR
    Weitzel, E
    Stewart, MG
    Donovan, DT
    Parke, RB
    Rodriguez, M
    [J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2003, 128 (01) : 103 - 108
  • [4] The validity and reliability of the reflux finding score (RFS)
    Belafsky, PC
    Postma, GN
    Koufman, JA
    [J]. LARYNGOSCOPE, 2001, 111 (08) : 1313 - 1317
  • [5] Validity and reliability of the reflux symptom index (RSI)
    Belafsky, PC
    Postma, GN
    Koufman, JA
    [J]. JOURNAL OF VOICE, 2002, 16 (02) : 274 - 277
  • [6] The Speaking Voice in the General Population: Normative Data and Associations to Sociodemographic and Lifestyle Factors
    Berg, Martin
    Fuchs, Michael
    Wirkner, Kerstin
    Loeffler, Markus
    Engel, Christoph
    Berger, Thomas
    [J]. JOURNAL OF VOICE, 2017, 31 (02) : 257.e13 - 257.e24
  • [7] Spirometry, measurement, and race in the nineteenth century
    Braun, L
    [J]. JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES, 2005, 60 (02) : 135 - 169
  • [8] Gender-related differences of hyaluronic acid distribution in the human vocal fold
    Butler, JE
    Hammond, TH
    Gray, SD
    [J]. LARYNGOSCOPE, 2001, 111 (05) : 907 - 911
  • [9] Polysaccharides from Citrus grandis L. Osbeck suppress inflammation and relieve chronic pharyngitis
    Chen, Liyan
    Lai, Yongfeng
    Dong, Lei
    Kang, Shasha
    Chen, Xiumei
    [J]. MICROBIAL PATHOGENESIS, 2017, 113 : 365 - 371
  • [10] Pathogenesis of Vocal Fold Nodules: New Insights from a Modelling Approach
    Dejonckere, Philippe H.
    Kob, Malte
    [J]. FOLIA PHONIATRICA ET LOGOPAEDICA, 2009, 61 (03) : 171 - 179