Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

被引：226

作者：

Magri, Giuliana ^{[1
]}

Miyajima, Michio ^{[2
]}

Bascones, Sabrina ^{[1
]}

Mortha, Arthur ^{[3
]}

Puga, Irene ^{[1
]}

Cassis, Linda ^{[1
]}

Barra, Carolina M. ^{[1
]}

Comerma, Laura ^{[1
]}

Chudnovskiy, Aleksey ^{[3
]}

Gentile, Maurizio ^{[1
]}

Llige, David ^{[1
]}

Cols, Montserrat ^{[4
]}

Serrano, Sergi ^{[5
,6
]}

Ignacio Arostegui, Juan ^{[7
]}

Juan, Manel ^{[7
]}

Yaguee, Jordi ^{[7
]}

Merad, Miriam ^{[3
,4
]}

Fagarasan, Sidonia ^{[2
]}

Cerutti, Andrea ^{[1
,4
,8
]}

机构：

[1] Inst Hosp del Mar Invest Med, Barcelona, Spain

[2] RIKEN Yokohama, RIKEN Ctr Integrat Med Sci, Lab Mucosal Immun, Yokohama, Kanagawa, Japan

[3] Icahn Sch Med Mt Sinai, Dept Med, Tisch Canc Inst, New York, NY USA

[4] Icahn Sch Med Mt Sinai, Dept Med, Inst Immunol, New York, NY USA

[5] Univ Autonoma Barcelona, Hosp del Mar, Dept Pathol, E-08193 Barcelona, Spain

[6] Univ Pompeu Fabra, Barcelona, Spain

[7] Hosp Clin Barcelona, Serv Immunol, Barcelona, Spain

[8] Barcelona Biomed Res Pk, Catalan Inst Res & Adv Studies, Barcelona, Spain

来源：

NATURE IMMUNOLOGY | 2014年 / 15卷 / 04期

基金：

欧洲研究理事会; 美国国家卫生研究院;

关键词：

ROR-GAMMA-T; TISSUE-INDUCER CELLS; GM-CSF; DIFFERENTIATION; EXPRESSION; SUBSETS; DRIVES; GUT; REQUIREMENT; HOMEOSTASIS;

D O I：

10.1038/ni.2830

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) regulate stromal cells, epithelial cells and cells of the immune system, but their effect on B cells remains unclear. Here we identified ROR gamma t(+) ILCs near the marginal zone (MZ), a splenic compartment that contains innate-like B cells highly responsive to circulating T cell-independent (TI) antigens. Splenic ILCs established bidirectional crosstalk with MAdCAM-1(+) marginal reticular cells by providing tumor-necrosis factor (TNF) and lymphotoxin, and they stimulated MZ B cells via B cell-activation factor (BAFF), the ligand of the costimulatory receptor CD40 (CD40L) and the Notch ligand Delta-like 1 (DLL1). Splenic ILCs further helped MZ B cells and their plasma-cell progeny by coopting neutrophils through release of the cytokine GM-CSF. Consequently, depletion of ILCs impaired both pre- and post-immune TI antibody responses. Thus, ILCs integrate stromal and myeloid signals to orchestrate innate-like antibody production at the interface between the immune system and circulatory system.

引用

页码：354 / +

页数：13

共 54 条

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