MiRNA in melanoma-derived exosomes

被引：99
|
作者：
Gajos-Michniewicz, Anna [1 ]
Duechler, Markus [2 ]
Czyz, Malgorzata [1 ]
机构：
[1] Med Univ Lodz, Dept Mol Biol Cancer, PL-92215 Lodz, Poland
[2] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, Lodz, Poland
来源：
CANCER LETTERS | 2014年 / 347卷 / 01期
关键词：
Biomarker; Exosome; Melanoma; MicroRNA; MiRNA; MESENCHYMAL STEM-CELLS; PROMOTE TUMOR-GROWTH; MICRORNA DYSREGULATION; CIRCULATING MICRORNAS; EPIGENETIC REGULATION; MALIGNANT-MELANOMA; MEMBRANE-VESICLES; CANCER; GENE; EXPRESSION;
D O I：
10.1016/j.canlet.2014.02.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Proteins, RNAs and viruses can be spread through exosomes, therefore transport utilizing these nanovesides is of the great interest. MiRNAs are common exosomal constituents capable of influencing expression of a variety of target genes. MiRNA signatures of exosomes are unique in cancer patients and differ from those in normal controls. The knowledge about miRNA profiles of tumor-derived exosomes may contribute to better diagnosis, determination of tumor progression and response to treatment, as well as to the development of targeted therapies. We summarize the current knowledge with regard to miRNAs that are found in exosomes derived from tumors, particularly from melanoma. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：29 / 37
页数：9
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