Synthesis of glyco(lipo) peptides by liposome-mediated native chemical Ligation

被引：36

作者：

Ingale, Sampat ^{[1
]}

Buskas, Therese ^{[1
]}

Boons, Geert-Jan ^{[1
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 25期

关键词：

D O I：

10.1021/ol062423x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Although native chemical ligation (NCL) is emerging as a powerful method for the assembly of (glyco) peptide building blocks, its applicability is reduced when peptide segments are poorly soluble in aqueous buffer. We have found that incorporating reactants in liposomes allows NCL of lipophilic peptides and lipopeptides. Furthermore, the reaction rates of liposome-mediated NCL are higher than traditional reaction conditions resulting in improved yields.

引用

页码：5785 / 5788

页数：4

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