Compared with casein or total milk protein, digestion of milk soluble proteins is too rapid to sustain the anabolic postprandial amino acid requirement

被引:133
|
作者
Lacroix, Magali
Bos, Cecile
Leonil, Joelle
Airinei, Gheorge
Luengo, Catherine
Dare, Sophie
Benamouzig, Robert
Fouillet, Helene
Fauquant, Jacques
Tome, Daniel
Gaudichon, Claire
机构
[1] INAPG, UMR 914, Physiol Nutr & Feeding Control Unit, INRA, F-75231 Paris 05, France
[2] Avicenne Hosp, CRNH Ile France, Gastroenterol Unit, Bobigny, France
[3] Milk Technol Res Lab Rennes, Rennes, France
来源
AMERICAN JOURNAL OF CLINICAL NUTRITION | 2006年 / 84卷 / 05期
关键词
milk proteins; humans; amino acid kinetics; protein metabolism; deamination;
D O I
10.1093/ajcn/84.5.1070
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The in vivo quality of milk protein fractions has seldom been studied in humans. Objective: Our objective was to compare the postprandial utilization of dietary nitrogen from 3 [N-15]-labeled milk products: micellar caseins (MC), milk soluble protein isolate (MSPI), and total milk protein (TMP). Design: The macronutrient intakes of 23 healthy volunteers were standardized for 1 wk, after which time the subjects ingested a meal containing MC (n = 8), MSPI (n = 7), or TMP (n = 8). [N-15] was measured for an 8-h period in plasma amino acids, proteins, and urea and in urinary urea. Results: The transfer of dietary nitrogen to urea occurred earlier after MSPI ingestion than after MC and TMP ingestion, and concentrations remained high for 8 h, concomitantly with higher but transient hyperaminoacidemia and a higher incorporation of dietary nitrogen into plasma amino acids. In contrast, deamination, postprandial hyperaminoacidemia, and the incorporation of dietary nitrogen into plasma amino acids were lower in the MC and TMP groups. Finally, total postprandial deamination values were 18.5 +/- 2.9%, 21.1 +/- 2.8%, and 28.2 +/- 2.9% of ingested nitrogen in the TMP, MC, and MSPI groups, respectively. Conclusions: Our results confirm the major role of kinetics in dietary nitrogen postprandial utilization and highlight the paradox of MSPI, which, despite its high Protein Digestibility Corrected Amino Acid Score, ensures a rate of amino acid delivery that is too rapid to sustain the anabolic requirement during the postprandial period. Milk proteins had the best nutritional quality, which suggested a synergistic effect between soluble proteins and caseins.
引用
收藏
页码:1070 / 1079
页数:10
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