Arylsulfonyl acridinyl derivatives acting on Plasmodium falciparum

被引：25
作者：
Santelli-Rouvier, C
Pradines, B
Berthelot, M
Parzy, D
Barbe, J
机构：
[1] Univ Mediterranee, Fac Pharm, CNRS, UMR 6009,GERCTOP, F-13385 Marseille 5, France
[2] Inst Trop Med, Serv St Armees, F-13998 Marseille, France
[3] Univ Nantes, Fac Sci & Tech, Lab Spectrochim, F-44322 Nantes, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 09期
关键词：
acridinic sulfone; Plasmodium falciparum; PABA;
D O I：
10.1016/j.ejmech.2004.05.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several arylacridinyl sulfones have been synthesized and their antimalarial action was tested on Plasmodium falciparum. PABA (para-aminobenzoic acid) has no antagonistic effect with these compounds as opposed to the observed effect with dapsone and sulfonamides previously studied. A possible relationship between the ability of cleavage of the S-9C acridinic bond and activity is suggested. (C) 2004 Elsevier SAS. All rights reserved.
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收藏
页码：735 / 744
页数：10
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