Nano-Hydroxyapatite Composite Biomaterials for Bone Tissue Engineering-A Review

被引：275
作者：
Venkatesan, Jayachandran [1 ]
Kim, Se-Kwon [1 ]
机构：
[1] Pukyong Natl Univ, Dept Marine Bio Convergence Sci, Pusan 608737, South Korea
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2014年 / 10卷 / 10期
关键词：
Nano-Hydroxyapatite; Chitosan; Collagen; Polylactic Acid; Bone; Tissue Engineering; MESENCHYMAL STEM-CELLS; IN-VITRO; OSTEOGENIC DIFFERENTIATION; NANOCOMPOSITE SCAFFOLDS; CALCIUM-PHOSPHATE; ACID) COMPOSITE; MECHANICAL-PROPERTIES; POLY(LACTIC-CO-GLYCOLIC ACID); INJECTABLE POLYURETHANES; POLY(VINYL ALCOHOL);
D O I：
10.1166/jbn.2014.1893
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In recent years, significant development has been achieved in the construction of artificial bone with ceramics, polymers and metals. Nano-hydroxyapatite (nHA) is widely used bioceramic material for bone graft substitute owing to its biocompatibility and osteoconductive properties. nHA with chitin, chitosan, collagen, gelatin, fibrin, polylactic acid, polycaprolactone, poly(lactic-co-glycolic) acid, polyamide, polyvinyl alcohol, polyurethane and polyhydroxybutyrate based composite scaffolds have been explored in the present review for bone graft substitute. This article further reviews the preparative methods, chemical interaction, biocompatibility, biodegradation, alkaline phosphatase activity, mineralization effect, mechanical properties and delivery of nHA-based nanocomposites for bone tissue regeneration. The nHA based composite biomaterials proved to be promising biomaterials for bone tissue engineering.
引用
收藏
页码：3124 / 3140
页数：17
相关论文
共 211 条
[1]   Super-hydrophilic electrospun nylon-6/hydroxyapatite membrane for bone tissue engineering [J].
Abdal-hay, Abdalla ;
Pant, Hem Raj ;
Lim, Jae Kyoo .
EUROPEAN POLYMER JOURNAL, 2013, 49 (06) :1314-1321
[2]   Air jet spinning of hydroxyapatite/poly(lactic acid) hybrid nanocomposite membrane mats for bone tissue engineering [J].
Abdal-haya, Abdalla ;
Sheikh, Faheem A. ;
Lim, Jae Kyoo .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 102 :635-643
[3]   Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications [J].
Adhikari, Raju ;
Gunatillake, Pathiraja A. ;
Griffiths, Ian ;
Tatai, Lisa ;
Wickramaratna, Malsha ;
Houshyar, Shadi ;
Moore, Tim ;
Mayadunne, Roshan T. M. ;
Field, John ;
McGee, Margaret ;
Carbone, Tania .
BIOMATERIALS, 2008, 29 (28) :3762-3770
[4]   Nano iron oxide-hydroxyapatite composite ceramics with enhanced radiopacity [J].
Ajeesh, M. ;
Francis, B. F. ;
Annie, John ;
Varma, P. R. Harikrishna .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (05) :1427-1434
[5]  
[Anonymous], 2013, ASIAN J BIOMED PHARM
[6]   Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization [J].
Asefnejad, Azadeh ;
Behnamghader, Aliasghar ;
Khorasani, Mohammad Taghi ;
Farsadzadeh, Babak .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 6 :93-100
[7]  
Azami M., 2006, P INT C BIOM PHARM E
[8]   Glutaraldehyde Cross linked Gelatin/hydroxyapatite Nanocomposite Scaffold, Engineered via Compound Techniques [J].
Azami, Mahmoud ;
Rabiee, Mohammad ;
Moztarzadeh, Fathollah .
POLYMER COMPOSITES, 2010, 31 (12) :2112-2120
[9]   Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components [J].
Barry, F ;
Boynton, RE ;
Liu, BS ;
Murphy, JM .
EXPERIMENTAL CELL RESEARCH, 2001, 268 (02) :189-200
[10]   Electrospinning collagen and elastin: Preliminary vascular tissue engineering [J].
Boland, ED ;
Matthews, JA ;
Pawlowski, KJ ;
Simpson, DG ;
Wnek, GE ;
Bowlin, GL .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 :1422-1432
12345678910