Nucleus-Targeted Drug Delivery: Theoretical Optimization of Nanoparticles Decoration for Enhanced Intracellular Active Transport

被引：43

作者：

Cohen, Ohad ^{[1
]}

Granek, Rony ^{[1
,2
]}

机构：

[1] Ben Gurion Univ Negev, Stella & Avram Goren Goldstein Dept Biotechnol En, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Ilse Katz Inst Meso & Nanoscale Sci & Technol, IL-84105 Beer Sheva, Israel

来源：

NANO LETTERS | 2014年 / 14卷 / 05期

关键词：

Drug delivery; active transport; processivity time; intracellular transport; nanoparticles; nanocarriers; MOLECULAR MOTORS; GENE DELIVERY; NANO DEVICE; DYNEIN; PROCESSIVITY; MICROTUBULES; ADENOVIRUS; PEPTIDES;

D O I：

10.1021/nl500248q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rational design for a nanoparticle is suggested, which will maximize its arrival efficiency from the plasma membrane to the nuclear surrounding. The design is based on grafting the particle surface with polymer spacers, each ending with a motor protein associating molecule, for example, nuclear localization signal peptide. It is theoretically shown that the spacer polymer molecular weight can be adjusted to significantly increase the effective particle processivity time. This should lead to appreciable enhancement of active transport of the nanocarrier, and consequently drug delivery, to the nucleus.

引用

页码：2515 / 2521

页数：7

共 44 条

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