Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications

被引：332

作者：

Skilling, Kathryn J. ^{[1
]}

Citossi, Francesca ^{[1
]}

Bradshaw, Tracey D. ^{[1
]}

Ashford, Marianne ^{[2
]}

Kellam, Barrie ^{[1
]}

Marlow, Maria ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

SOFT MATTER | 2014年 / 10卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

SUGAR-INTEGRATED GELATORS; PEPTIDE-BASED HYDROGELS; AMINO-ACID DERIVATIVES; WEIGHT HYDROGELATORS; MECHANICAL-PROPERTIES; SUPRAMOLECULAR HYDROGEL; FMOC-DIPHENYLALANINE; CONTROLLED-RELEASE; PHYSICAL GELATION; L-ALANINE;

D O I：

10.1039/c3sm52244j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In recent years low molecular mass organic gelators (LMOGs) have gained increasing interest as an alternative biomaterial to polymer derived gels, with potential applications in drug delivery and tissue engineering. LMOGs are small organic molecules which self-assemble in water or organic solvents forming a 3D network that entraps the liquid phase resulting in gel formation. In this review, we report the classification of LMOGs into hydrogelators and gelators of organic solvents and we discuss the techniques commonly used to characterise the gels of these gelators with particular reference to specific applications of LMOGs in drug delivery and tissue engineering.

引用

页码：237 / 256

页数：20

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