Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis

被引:4
作者
Ni, Siyang
Jiang, Bingya
Wu, Linzhuan [1 ]
Wang, Yiguang
Zhou, Hongxia
He, Weiqing
Wang, Hongyuan
Zhu, Jianhua
Li, Shufen
Li, Ting
Zhang, Kan
机构
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Minist Hlth, Key Lab Biotechnol Antibiot, Beijing 100050, Peoples R China
基金
中国国家自然科学基金;
关键词
6-demethoxy-6-methylgeldanamycin; geldanamycin biosynthesis; Streptomyces hygroscopicus 17997; SUBSTRATE-SPECIFICITY; GENE-CLUSTER; POLYKETIDE; ANALOGS; SYNTHASE; PRODUCTS; DOMAINS; MUTANT;
D O I
10.1038/ja.2013.94
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页码:183 / 185
页数:3
相关论文
共 29 条
[1]   GELDANAMYCIN, A NEW ANTIBIOTIC [J].
DEBOER, C ;
MEULMAN, PA ;
WNUK, RJ ;
PETERSON, DH .
JOURNAL OF ANTIBIOTICS, 1970, 23 (09) :442-&
[2]   Broad Substrate Specificity of the Amide Synthase in S. hygroscopicus-New 20-Membered Macrolactones Derived from Geldanamycin [J].
Eichner, Simone ;
Eichner, Timo ;
Floss, Heinz G. ;
Fohrer, Joerg ;
Hofer, Edgar ;
Sasse, Florenz ;
Zeilinger, Carsten ;
Kirschning, Andreas .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (03) :1673-1679
[3]   New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis [J].
Eichner, Simone ;
Floss, Heinz G. ;
Sasse, Florenz ;
Kirschning, Andreas .
CHEMBIOCHEM, 2009, 10 (11) :1801-1805
[4]   Geldanamycin and its anti-cancer activities [J].
Fukuyo, Yayoi ;
Hunt, Clayton R. ;
Horikoshi, Nobuo .
CANCER LETTERS, 2010, 290 (01) :24-35
[5]   A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer [J].
Gartner, Elaina M. ;
Silverman, Paula ;
Simon, Michael ;
Flaherty, Lawrence ;
Abrams, Judith ;
Ivy, Percy ;
LoRusso, Patricia M. .
BREAST CANCER RESEARCH AND TREATMENT, 2012, 131 (03) :933-937
[6]   Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin [J].
Hong, YS ;
Lee, D ;
Kim, W ;
Jeong, JK ;
Kim, CG ;
Sohng, JK ;
Lee, JH ;
Paik, SG ;
Lee, JJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (36) :11142-11143
[7]   The methoxymalonyl-acyl carrier protein biosynthesis locus and the nearby gene with the β-ketoacyl synthase domain are involved in the biosynthesis of galbonolides in Streptomyces galbus, but these loci are separate from the modular polyketide synthase gene cluster [J].
Karki, Suman ;
Kwon, So-Yeon ;
Yoo, Hye-Gyeong ;
Suh, Joo-Won ;
Park, Si-Hyung ;
Kwon, Hyung-Jin .
FEMS MICROBIOLOGY LETTERS, 2010, 310 (01) :69-75
[8]   A tylosin ketoreductase reveals how chirality is determined in polyketides [J].
Keatinge-Clay, Adrian T. .
CHEMISTRY & BIOLOGY, 2007, 14 (08) :898-908
[9]   Isolation and Structure of Homotemsirolimuses A, B, and C [J].
Kong, Fangming ;
Zhu, Tianmin ;
Yu, Ker ;
Pagano, Thomas G. ;
Desai, Parimal ;
Radebaugh, Galen ;
Fawzi, Mandi .
JOURNAL OF NATURAL PRODUCTS, 2011, 74 (04) :547-553
[10]   Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases [J].
Kwan, David H. ;
Sun, Yuhui ;
Schulz, Frank ;
Hong, Hui ;
Popovic, Bojana ;
Sim-Stark, Joalice C. C. ;
Haydock, Stephen F. ;
Leadlay, Peter F. .
CHEMISTRY & BIOLOGY, 2008, 15 (11) :1231-1240