Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections

被引：22

作者：

Bryan, Arielle M. ^{[1
]}

Del Poeta, Maurizio ^{[1
]}

Luberto, Chiara ^{[2
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

来源：

MEDIATORS OF INFLAMMATION | 2015年 / 2015卷

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; CRYPTOCOCCUS-NEOFORMANS; CANDIDA-ALBICANS; ALVEOLAR MACROPHAGES; HOST-DEFENSE; LIPID RAFTS; EXTRACELLULAR TRAPS; NEUTROPHIL FUNCTION; DENDRITIC CELLS; IN-VITRO;

D O I：

10.1155/2015/640540

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to play an important role in many cell functions, including the function of phagocytes. In this review, we discuss major findings that relate to the importance of sphingolipids in macrophage and neutrophil function and the role of macrophages and neutrophils in the most common types of fungal infections, as well as studies that have linked these three concepts to show the importance of sphingolipid signaling in immune response to fungal infections.

引用

页数：12

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