IL-17 and Th17 cells in human inflammatory diseases

被引：239
|
作者：
Miossec, Pierre [1 ,2 ]
机构：
[1] Hop Edouard Herriot, Dept Immunol & Rheumatol, Lyon, France
[2] Univ Lyon, Immunogenom & Inflammat Res Unit EA 4130, Lyon, France
来源：
MICROBES AND INFECTION | 2009年 / 11卷 / 05期
关键词：
IL-17; Cytokines; Inflammation; Destruction; TNF alpha; IL-1; ACTIVE CROHNS-DISEASE; TUMOR-NECROSIS-FACTOR; HYPER-IGE SYNDROME; RHEUMATOID-ARTHRITIS; AUTOIMMUNE ENCEPHALOMYELITIS; T-CELLS; INTERLEUKIN (IL)-17; MONOCLONAL-ANTIBODY; COLLAGEN ARTHRITIS; BONE EROSION;
D O I：
10.1016/j.micinf.2009.04.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target. (C) 2009 Elsevier Masson SAS. All fights reserved.
引用
收藏
页码：625 / 630
页数：6
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