Intestinal microvascular endothelium and innate immunity in inflammatory bowel disease: A second line of defense?

被引:37
作者
Heidemann, Jan [1 ]
Domschke, Wolfram [1 ]
Kucharzik, Torsten [1 ]
Maaser, Christian [1 ]
机构
[1] Univ Munster, Dept Med B, D-48129 Munster, Germany
关键词
D O I
10.1128/IAI.00248-06
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:5425 / 5432
页数:8
相关论文
共 88 条
[1]   Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease [J].
Abreu, MT ;
Taylor, KD ;
Lin, YC ;
Hang, T ;
Gaiennie, J ;
Landers, CJ ;
Vasiliauskas, EA ;
Kam, LY ;
Rojany, M ;
Papadakis, KA ;
Rotter, JI ;
Targan, SR ;
Yang, HY .
GASTROENTEROLOGY, 2002, 123 (03) :679-688
[2]   TLR signaling in the gut in health and disease [J].
Abreu, MT ;
Fukata, M ;
Arditi, M .
JOURNAL OF IMMUNOLOGY, 2005, 174 (08) :4453-4460
[3]   Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NFκB-independent pathway [J].
Akhtar, M ;
Watson, JL ;
Nazli, A ;
McKay, DM .
FASEB JOURNAL, 2003, 17 (08) :1319-+
[4]   Recognition of pathogen-associated molecular patterns by TLR family [J].
Akira, S ;
Hemmi, H .
IMMUNOLOGY LETTERS, 2003, 85 (02) :85-95
[5]   Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].
Alexopoulou, L ;
Holt, AC ;
Medzhitov, R ;
Flavell, RA .
NATURE, 2001, 413 (6857) :732-738
[6]   Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence [J].
Alvarez-Lobos, M ;
Arostegui, JI ;
Sans, M ;
Tassies, D ;
Plaza, S ;
Delgado, S ;
Lacy, AM ;
Pique, JM ;
Yagüe, J ;
Panés, J .
ANNALS OF SURGERY, 2005, 242 (05) :693-700
[7]   Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells [J].
Baumgart, DC ;
Metzke, D ;
Schmitz, J ;
Scheffold, A ;
Sturm, A ;
Wiedenmann, B ;
Dignass, AU .
GUT, 2005, 54 (02) :228-236
[8]  
Beck GC, 1999, CLIN EXP IMMUNOL, V118, P298
[9]  
Berg EL, 1998, AM J PATHOL, V152, P469
[10]   REGULATION OF THE FIBRINOLYTIC SYSTEM OF CULTURED HUMAN VASCULAR ENDOTHELIUM BY INTERLEUKIN-1 [J].
BEVILACQUA, MP ;
SCHLEEF, RR ;
GIMBRONE, MA ;
LOSKUTOFF, DJ .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (02) :587-591