Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging

被引：32
作者：
Babaei, A. [3 ]
Bhargava, V.
Aalam, S.
Scadeng, M. [2 ]
Mittal, R. K. [1 ]
机构：
[1] Univ Calif San Diego, Div Gastroenterol, VA Med Ctr, San Diego, CA 92161 USA
[2] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA
[3] Med Coll Wisconsin, Div Gastroenterol & Hepatol, Milwaukee, WI 53226 USA
来源：
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2009年 / 29卷 / 08期
关键词：
SOLID MEAL; ACID-SECRETION; MOTILITY; ACCOMMODATION; VARIABILITY; DISTENSION; MECHANISMS; STOMACH; LIQUID; REFLUX;
D O I：
10.1111/j.1365-2036.2009.03947.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro-oesophageal reflux by decreasing acid secretion. To determine the effect of PPI therapy on the gastric volume after a standard meal. A total of nine healthy subjects were studied using magnetic resonance imaging, before and after a standard liquid meal mixed with a paramagnetic contrast to help demarcate the gastric region. Images were acquired for a total of 90 min after the meal. Studies were conducted before and following esomeprazole twice daily for 7 days. Images were analysed to determine the gastric liquid volume. Gastric volume, 15 min after the meal peaked to 611 +/- 37 mL on the control day and 539 +/- 30 mL following the PPI administration (P < 0.001). Average gastric volume remained significantly lower (56 +/- 9 mL, P < 0.05) on the PPI therapy from 5 to 75 min after the meal. Proton pump inhibitor therapy causes a significant reduction in the gastric contents volume during first 75 min after the meal. In addition to increasing the gastric pH, PPI therapy may decrease the frequency of gastro-oesophageal reflux by decreasing the volume of gastric contents.
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页码：863 / 870
页数：8
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