Serum LDH: A marker of disease activity and its response to therapy in idiopathic pulmonary fibrosis

被引：28
作者：
vanKrugten, M
Cobben, NAM
Lamers, RJS
vanDieijenVisser, MP
Wagenaar, SS
Wouters, EFM
Drent, M
机构：
[1] UNIV HOSP,DEPT PULMONOL,MAASTRICHT,NETHERLANDS
[2] UNIV HOSP,DEPT DIAGNOST RADIOL,MAASTRICHT,NETHERLANDS
[3] UNIV HOSP,DEPT CLIN CHEM,MAASTRICHT,NETHERLANDS
[4] UNIV HOSP,DEPT PATHOL,MAASTRICHT,NETHERLANDS
来源：
NETHERLANDS JOURNAL OF MEDICINE | 1996年 / 48卷 / 06期
关键词：
lactate dehydrogenase (LDH); idiopathic pulmonary fibrosis (IPF); cryptogenic fibrosing alveolitis;
D O I：
10.1016/0300-2977(95)00074-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the following case report the determination of serum lactate dehydrogenase (LDH)-a simple though non-specific test -reflects changes of disease activity and clinical improvement during treatment with cyclophosphamide and a tapered dose of prednisone from 100 to 0 mg daily in a 43-year-old woman with idiopathic pulmonary fibrosis. The trend observed in this case indicates that the serum LDH-activity may be directly proportional to the extent of this diffuse inflammatory pulmonary disease.
引用
收藏
页码：220 / 223
页数：6
相关论文
共 14 条
[1]   OUTCOME OF SUBJECTS WITH IDIOPATHIC PULMONARY FIBROSIS WHO FAIL CORTICOSTEROID-THERAPY - IMPLICATIONS FOR FURTHER-STUDIES [J].
DAYTON, CS ;
SCHWARTZ, DA ;
HELMERS, RA ;
PUERINGER, RJ ;
GILBERT, SR ;
MERCHANT, RK ;
HUNNINGHAKE, GW .
CHEST, 1993, 103 (01) :69-73
[2]  
DEREMEE RA, 1986, JAMA-J AM MED ASSOC, V204, P1193
[3]   A computer program using BALF-analysis results as a diagnostic tool in interstitial lung diseases [J].
Drent, M ;
vanNierop, AMF ;
Gerritsen, FA ;
Wouters, EFM ;
Mulder, PGH .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (02) :736-741
[4]   PULMONARY FIBROSIS [J].
DUNNILL, MS .
HISTOPATHOLOGY, 1990, 16 (04) :321-329
[5]  
HAGEDORN JE, 1971, AM J PATHOL, V64, P575
[6]   RANDOMIZED CONTROLLED TRIAL COMPARING PREDNISOLONE ALONE WITH CYCLOPHOSPHAMIDE AND LOW-DOSE PREDNISOLONE IN COMBINATION IN CRYPTOGENIC FIBROSING ALVEOLITIS [J].
JOHNSON, MA ;
KWAN, S ;
SNELL, NJC ;
NUNN, AJ ;
DARBYSHIRE, JH ;
TURNERWARWICK, M .
THORAX, 1989, 44 (04) :280-288
[7]  
Lott J., 1987, CLIN ENZYMOLOGY CASE, P213
[8]  
MATUSIEWICZ SP, 1993, EUR RESPIR J, V6, P1282
[9]  
PANUS PC, 1989, IN VITRO CELL DEV B, V25, P821
[10]   LACTATE-DEHYDROGENASE ACTIVITY AND ISOZYME PATTERNS IN TISSUES AND BRONCHOALVEOLAR LAVAGE FLUID FROM RATS TREATED WITH MONOCROTALINE PYRROLE [J].
SCHULTZE, AE ;
GUNAGA, KP ;
WAGNER, JG ;
HOORN, CM ;
MOOREHEAD, WR ;
ROTH, RA .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1994, 126 (02) :301-310
12