Caspases and caspase inhibitors

被引：534

作者：

Villa, P ^{[1
]}

Kaufmann, SH ^{[1
]}

Earnshaw, WC ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN, DIV ONCOL RES, ROCHESTER, MN 55901 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(97)01107-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and pharmacological caspase inhibitors.

引用

页码：388 / 393

页数：6

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