Application of an Improved Ultrasound Full-Waveform Inversion in Bone Quantitative Measurement

Inspired by the large number of applications for symmetric nonlinear equations, an improved full waveform inversion algorithm is proposed in this paper in order to quantitatively measure the bone density and realize the early diagnosis of osteoporosis. The isotropic elastic wave equation is used to simulate ultrasonic propagation between bone and soft tissue, and the Gauss-Newton algorithm based on symmetric nonlinear equations is applied to solve the optimal solution in the inversion. In addition, the authors use several strategies including the frequency-grid multiscale method, the envelope inversion and the new joint velocity-density inversion to improve the result of conventional full-waveform inversion method. The effects of various inversion settings are also tested to find a balanced way of keeping good accuracy and high computational efficiency. Numerical inversion experiments showed that the improved full waveform inversion (FWI) method proposed in this paper shows superior inversion results as it can detect small velocity-density changes in bones, and the relative error of the numerical model is within 10%. This method can also avoid interference from small amounts of noise and satisfy the high precision requirements for quantitative ultrasound measurements of bone.