Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

被引：12

作者：

Albertario, Ambra ^{[1
]}

Swim, Megan M. ^{[1
]}

Ahmed, Eltayeb Mohamed ^{[1
]}

Iacobazzi, Dominga ^{[1
]}

Yeong, Michael ^{[1
]}

Madeddu, Paolo ^{[1
]}

Ghorbel, Mohamed T. ^{[1
]}

Caputo, Massimo ^{[1
]}

机构：

[1] Univ Bristol, Bristol Heart Inst, Res Level 7,Upper Maudlin St, Bristol BS2 8HW, Avon, England

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2019年 / 4卷 / 03期

基金：

英国医学研究理事会;

关键词：

congenital heart disease; reconstruction; right ventricular outflow swine model; tissue engineering; tract stem cells; EXTRACELLULAR-MATRIX; PRELIMINARY EXPERIENCE; REPAIRED TETRALOGY; VALVES; DIFFERENTIATION; THERAPY; FALLOT;

D O I：

10.1016/j.jacbts.2019.02.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellutar grafts. To the authors' knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：364 / 384

页数：21

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